http://purl.uniprot.org/citations/24983365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/24983365 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundMAGE-A (melanoma-associated antigen-A) are promising targets for specific immunotherapy and their expression may be induced by the epigenetic factor BORIS.MethodsTo determine their relevance for breast cancer, we quantified the levels of MAGE-A1, -A2, -A3, -A12 and BORIS mRNA, as well as microRNAs let-7b and miR-202 in pre- and postoperative serum of 102 and 34 breast cancer patients, respectively, and in serum of 26 patients with benign breast diseases and 37 healthy women by real-time PCR. The mean follow-up time of the cancer patients was 6.2 years.ResultsThe serum levels of MAGE-A and BORIS mRNA, as well as let-7b were significantly higher in patients with invasive carcinomas than in patients with benign breast diseases or healthy women (P<0.001), whereas the levels of miR-202 were elevated in both patient cohorts (P<0.001). In uni- and multivariate analyses, high levels of miR-202 significantly correlated with poor overall survival (P=0.0001). Transfection of breast cancer cells with synthetic microRNAs and their inhibitors showed that let-7b and miR-202 did not affect the protein expression of MAGE-A1.ConclusionsBased on their cancer-specific increase in breast cancer patients, circulating MAGE-A and BORIS mRNAs may be further explored for early detection of breast cancer and monitoring of MAGE-directed immunotherapies. Moreover, serum miR-202 is associated with prognosis."xsd:string |
http://purl.uniprot.org/citations/24983365 | http://purl.org/dc/terms/identifier | "doi:10.1038/bjc.2014.360"xsd:string |
http://purl.uniprot.org/citations/24983365 | http://purl.uniprot.org/core/author | "Muller V."xsd:string |
http://purl.uniprot.org/citations/24983365 | http://purl.uniprot.org/core/author | "Joosse S.A."xsd:string |
http://purl.uniprot.org/citations/24983365 | http://purl.uniprot.org/core/author | "Pantel K."xsd:string |
http://purl.uniprot.org/citations/24983365 | http://purl.uniprot.org/core/author | "Schwarzenbach H."xsd:string |
http://purl.uniprot.org/citations/24983365 | http://purl.uniprot.org/core/author | "Steinbach B."xsd:string |
http://purl.uniprot.org/citations/24983365 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
http://purl.uniprot.org/citations/24983365 | http://purl.uniprot.org/core/name | "Br J Cancer"xsd:string |
http://purl.uniprot.org/citations/24983365 | http://purl.uniprot.org/core/pages | "909-917"xsd:string |
http://purl.uniprot.org/citations/24983365 | http://purl.uniprot.org/core/title | "Circulating cell-free cancer-testis MAGE-A RNA, BORIS RNA, let-7b and miR-202 in the blood of patients with breast cancer and benign breast diseases."xsd:string |
http://purl.uniprot.org/citations/24983365 | http://purl.uniprot.org/core/volume | "111"xsd:string |
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