| http://purl.uniprot.org/citations/24987331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24987331 | http://www.w3.org/2000/01/rdf-schema#comment | "The maturation of the GABAergic system is a crucial determinant of cortical development during early postnatal life, when sensory circuits undergo a process of activity-dependent refinement. An altered excitatory/inhibitory balance has been proposed as a possible pathogenic mechanism of autism spectrum disorders (ASD). The homeobox-containing transcription factor Engrailed-2 (En2) has been associated to ASD, and En2 knockout (En2 (-/-)) mice show ASD-like features accompanied by a partial loss of cortical GABAergic interneurons. Here we studied GABAergic markers and cortical function in En2 (-/-) mice, by exploiting the well-known anatomical and functional features of the mouse visual system. En2 is expressed in the visual cortex at postnatal day 30 and during adulthood. When compared to age-matched En2 (+/+) controls, En2 (-/-) mice showed an increased number of parvalbumin (PV(+)), somatostatin (SOM(+)), and neuropeptide Y (NPY(+)) positive interneurons in the visual cortex at P30, and a decreased number of SOM(+) and NPY(+) interneurons in the adult. At both ages, the differences in distinct interneuron populations observed between En2 (+/+) and En2 (-/-) mice were layer-specific. Adult En2 (-/-) mice displayed a normal eye-specific segregation in the retino-geniculate pathway, and in vivo electrophysiological recordings showed a normal development of basic functional properties (acuity, response latency, receptive field size) of the En2 (-/-) primary visual cortex. However, a significant increase of binocularity was found in P30 and adult En2 (-/-) mice, as compared to age-matched controls. Differently from what observed in En2 (+/+) mice, the En2 (-/-) primary visual cortex did not respond to a brief monocular deprivation performed between P26 and P29, during the so-called "critical period." These data suggest that altered GABAergic circuits impact baseline binocularity and plasticity in En2 (-/-) mice, while leaving other visual functional properties unaffected."xsd:string |
| http://purl.uniprot.org/citations/24987331 | http://purl.org/dc/terms/identifier | "doi:10.3389/fncel.2014.00163"xsd:string |
| http://purl.uniprot.org/citations/24987331 | http://purl.uniprot.org/core/author | "Allegra M."xsd:string |
| http://purl.uniprot.org/citations/24987331 | http://purl.uniprot.org/core/author | "Bozzi Y."xsd:string |
| http://purl.uniprot.org/citations/24987331 | http://purl.uniprot.org/core/author | "Cenni M.C."xsd:string |
| http://purl.uniprot.org/citations/24987331 | http://purl.uniprot.org/core/author | "Caleo M."xsd:string |
| http://purl.uniprot.org/citations/24987331 | http://purl.uniprot.org/core/author | "Genovesi S."xsd:string |
| http://purl.uniprot.org/citations/24987331 | http://purl.uniprot.org/core/author | "Sgado P."xsd:string |
| http://purl.uniprot.org/citations/24987331 | http://purl.uniprot.org/core/author | "Zunino G."xsd:string |
| http://purl.uniprot.org/citations/24987331 | http://purl.uniprot.org/core/author | "Maggia M."xsd:string |
| http://purl.uniprot.org/citations/24987331 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24987331 | http://purl.uniprot.org/core/name | "Front Cell Neurosci"xsd:string |
| http://purl.uniprot.org/citations/24987331 | http://purl.uniprot.org/core/pages | "163"xsd:string |
| http://purl.uniprot.org/citations/24987331 | http://purl.uniprot.org/core/title | "Altered GABAergic markers, increased binocularity and reduced plasticity in the visual cortex of Engrailed-2 knockout mice."xsd:string |
| http://purl.uniprot.org/citations/24987331 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/24987331 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24987331 |
| http://purl.uniprot.org/citations/24987331 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24987331 |
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| http://purl.uniprot.org/uniprot/#_D3Z5S3-mappedCitation-24987331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24987331 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRU0-mappedCitation-24987331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24987331 |
| http://purl.uniprot.org/uniprot/#_D3Z466-mappedCitation-24987331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24987331 |
| http://purl.uniprot.org/uniprot/#_P57774-mappedCitation-24987331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24987331 |
| http://purl.uniprot.org/uniprot/#_P09066-mappedCitation-24987331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24987331 |
| http://purl.uniprot.org/uniprot/#_Q3TXX4-mappedCitation-24987331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24987331 |