http://purl.uniprot.org/citations/24990929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/24990929 | http://www.w3.org/2000/01/rdf-schema#comment | "Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an RNA-binding protein implicated in RNA metabolism. Here, we investigated the role of hnRNP K in synapse function. We demonstrated that hnRNP K regulates dendritic spine density and long-term potentiation (LTP) in cultured hippocampal neurons from embryonic rats. LTP requires the extracellular signal-regulated kinase (ERK)1/2-mediated phosphorylation and cytoplasmic accumulation of hnRNP K. Moreover, hnRNP K knockdown prevents ERK cascade activation and GluA1-S845 phosphorylation and surface delivery, which are essential steps for LTP. These findings establish hnRNP K as a new critical regulator of synaptic transmission and plasticity in hippocampal neurons."xsd:string |
http://purl.uniprot.org/citations/24990929 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.0303-14.2014"xsd:string |
http://purl.uniprot.org/citations/24990929 | http://purl.uniprot.org/core/author | "Passafaro M."xsd:string |
http://purl.uniprot.org/citations/24990929 | http://purl.uniprot.org/core/author | "D'Angelo E."xsd:string |
http://purl.uniprot.org/citations/24990929 | http://purl.uniprot.org/core/author | "Bassani S."xsd:string |
http://purl.uniprot.org/citations/24990929 | http://purl.uniprot.org/core/author | "Mapelli L."xsd:string |
http://purl.uniprot.org/citations/24990929 | http://purl.uniprot.org/core/author | "Sassone J."xsd:string |
http://purl.uniprot.org/citations/24990929 | http://purl.uniprot.org/core/author | "Prestori F."xsd:string |
http://purl.uniprot.org/citations/24990929 | http://purl.uniprot.org/core/author | "Folci A."xsd:string |
http://purl.uniprot.org/citations/24990929 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
http://purl.uniprot.org/citations/24990929 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
http://purl.uniprot.org/citations/24990929 | http://purl.uniprot.org/core/pages | "9088-9095"xsd:string |
http://purl.uniprot.org/citations/24990929 | http://purl.uniprot.org/core/title | "Loss of hnRNP K impairs synaptic plasticity in hippocampal neurons."xsd:string |
http://purl.uniprot.org/citations/24990929 | http://purl.uniprot.org/core/volume | "34"xsd:string |
http://purl.uniprot.org/citations/24990929 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24990929 |
http://purl.uniprot.org/citations/24990929 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24990929 |
http://purl.uniprot.org/uniprot/P61980#attribution-409275A4C33F68525FA0AB908F2B8036 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24990929 |
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http://purl.uniprot.org/uniprot/P61980#attribution-87E3DBA8B584D0DD78703BC96BA9DCEC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24990929 |
http://purl.uniprot.org/uniprot/P61980#attribution-CF51D97502FB450FF1F827065C2BA1E3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24990929 |
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