| http://purl.uniprot.org/citations/24994818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24994818 | http://www.w3.org/2000/01/rdf-schema#comment | "The IgM-Fc receptor (FcμR) is involved in IgM homeostasis as evidenced by increased pre-immune serum IgM and natural auto-antibodies of both IgM and IgG isotypes in Fcmr-deficient C57BL/6 (B6) mice. To determine the impact of Fcmr-ablation on autoimmunity, we introduced the Fcmr null mutation onto the Fas-deficient autoimmune-prone B6.MRL Fas (lpr/lpr) mouse background (B6/lpr). Both IgM and IgG auto-antibodies against dsDNA or chromatin appeared earlier in FcμR(-) B6/lpr than FcμR(+) B6/lpr mice, but this difference became less pronounced with age. Splenic B2 cells, which were 2-fold elevated in FcμR(+) B6/lpr mice, were reduced to normal B6 levels in FcμR(-) B6/lpr mice, whereas splenic B1 cells were comparable in both groups of B6/lpr mice. By contrast, marginal zone (MZ) B cells were markedly reduced in FcμR(-) B6/lpr mice compared with either FcμR(+) B6/lpr or wild type (WT) B6 mice. This reduction appeared to result from rapid differentiation of MZ B cells into plasma cells in the absence of FcμR, as IgM antibody to a Smith (Sm) antigen, to which MZ B cells are known to preferentially respond, was greatly increased in both groups (B6/lpr and B6) of FcμR(-) mice compared with FcμR(+) B6/lpr or B6 mice. Mott cells, aberrant plasma cells with intra-cytoplasmic inclusions, were also increased in the absence of FcμR. Despite these abnormalities, the severity of renal pathology and function and survival were all indistinguishable between FcμR(-) and FcμR(+) B6/lpr mice. Collectively, these findings suggest that FcμR plays important roles in the regulation of auto-antibody production, Mott cell formation and the differentiation of MZ B cells into plasma cells in B6.MRL Fas (lpr/lpr) mice."xsd:string |
| http://purl.uniprot.org/citations/24994818 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxu070"xsd:string |
| http://purl.uniprot.org/citations/24994818 | http://purl.uniprot.org/core/author | "Ohno H."xsd:string |
| http://purl.uniprot.org/citations/24994818 | http://purl.uniprot.org/core/author | "Takagi M."xsd:string |
| http://purl.uniprot.org/citations/24994818 | http://purl.uniprot.org/core/author | "Suzuki Y."xsd:string |
| http://purl.uniprot.org/citations/24994818 | http://purl.uniprot.org/core/author | "Izui S."xsd:string |
| http://purl.uniprot.org/citations/24994818 | http://purl.uniprot.org/core/author | "Kubagawa H."xsd:string |
| http://purl.uniprot.org/citations/24994818 | http://purl.uniprot.org/core/author | "Honjo K."xsd:string |
| http://purl.uniprot.org/citations/24994818 | http://purl.uniprot.org/core/author | "Kubagawa Y."xsd:string |
| http://purl.uniprot.org/citations/24994818 | http://purl.uniprot.org/core/author | "Bucy R.P."xsd:string |
| http://purl.uniprot.org/citations/24994818 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24994818 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/24994818 | http://purl.uniprot.org/core/pages | "659-672"xsd:string |
| http://purl.uniprot.org/citations/24994818 | http://purl.uniprot.org/core/title | "Enhanced auto-antibody production and Mott cell formation in FcmuR-deficient autoimmune mice."xsd:string |
| http://purl.uniprot.org/citations/24994818 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/24994818 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24994818 |
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