| http://purl.uniprot.org/citations/24996174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24996174 | http://www.w3.org/2000/01/rdf-schema#comment | "SIRT2 is a mammalian member of the Sirtuin family of NAD(+)-dependent protein deacetylases. The tyrosine kinase Src is involved in a variety of cellular signaling pathways, leading to the induction of DNA synthesis, cell proliferation, and cytoskeletal reorganization. The function of SIRT2 is modulated by post-translational modifications; however, the precise molecular signaling mechanism of SIRT2 through interactions with c-Src has not yet been established. In this study, we investigated the potential regulation of SIRT2 function by c-Src. We found that the protein levels of SIRT2 were decreased by c-Src, and subsequently rescued by the addition of a Src specific inhibitor, SU6656, or by siRNA-mediated knockdown of c-Src. The c-Src interacts with and phosphorylates SIRT2 at Tyr104. c-Src also showed the ability to regulate the deacetylation activity of SIRT2. Investigation on the phosphorylation of SIRT2 suggested that this was the method of c-Src-mediated SIRT2 regulation."xsd:string |
| http://purl.uniprot.org/citations/24996174 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2014.06.117"xsd:string |
| http://purl.uniprot.org/citations/24996174 | http://purl.uniprot.org/core/author | "Choi Y.H."xsd:string |
| http://purl.uniprot.org/citations/24996174 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/24996174 | http://purl.uniprot.org/core/author | "Jin Y.H."xsd:string |
| http://purl.uniprot.org/citations/24996174 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/24996174 | http://purl.uniprot.org/core/author | "Lee K.Y."xsd:string |
| http://purl.uniprot.org/citations/24996174 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24996174 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/24996174 | http://purl.uniprot.org/core/pages | "1120-1125"xsd:string |
| http://purl.uniprot.org/citations/24996174 | http://purl.uniprot.org/core/title | "Src regulates the activity of SIRT2."xsd:string |
| http://purl.uniprot.org/citations/24996174 | http://purl.uniprot.org/core/volume | "450"xsd:string |
| http://purl.uniprot.org/citations/24996174 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24996174 |
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