| http://purl.uniprot.org/citations/24996186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24996186 | http://www.w3.org/2000/01/rdf-schema#comment | "Depletion of Ca(2+) from the endoplasmic reticulum (ER) lumen triggers the opening of Ca(2+) release-activated Ca(2+) (CRAC) channels at the plasma membrane. CRAC channels are activated by stromal interaction molecule 1 (STIM1), an ER resident protein that senses Ca(2+) store depletion and interacts with Orai1, the pore-forming subunit of the channel. The subunit stoichiometry of the CRAC channel is controversial. Here we provide evidence, using atomic force microscopy (AFM) imaging, that Orai1 assembles as a hexamer, and that STIM1 binds to Orai1 with sixfold symmetry. STIM1 associates with Orai1 in the form of monomers, dimers, and multimeric string-like structures that form links between the Orai1 hexamers. Our results provide new insights into the nature of the interactions between STIM1 and Orai1."xsd:string |
| http://purl.uniprot.org/citations/24996186 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2014.06.054"xsd:string |
| http://purl.uniprot.org/citations/24996186 | http://purl.uniprot.org/core/author | "Edwardson J.M."xsd:string |
| http://purl.uniprot.org/citations/24996186 | http://purl.uniprot.org/core/author | "Murrell-Lagnado R.D."xsd:string |
| http://purl.uniprot.org/citations/24996186 | http://purl.uniprot.org/core/author | "Balasuriya D."xsd:string |
| http://purl.uniprot.org/citations/24996186 | http://purl.uniprot.org/core/author | "Srivats S."xsd:string |
| http://purl.uniprot.org/citations/24996186 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24996186 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/24996186 | http://purl.uniprot.org/core/pages | "2874-2880"xsd:string |
| http://purl.uniprot.org/citations/24996186 | http://purl.uniprot.org/core/title | "Atomic force microscopy (AFM) imaging suggests that stromal interaction molecule 1 (STIM1) binds to Orai1 with sixfold symmetry."xsd:string |
| http://purl.uniprot.org/citations/24996186 | http://purl.uniprot.org/core/volume | "588"xsd:string |
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