| http://purl.uniprot.org/citations/24996924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24996924 | http://www.w3.org/2000/01/rdf-schema#comment | "Antigen stimulation of mast cells via FcεRI, the high-affinity receptor for IgE, triggers a signaling cascade that requires Ca(2+) mobilization for exocytosis of secretory granules during the allergic response. To characterize the role of Rho GTPases in FcεRI signaling, we utilized a mutant RBL cell line, B6A4C1, that is deficient in antigen-stimulated Cdc42 activation important for these processes. Recently the importance of stimulated intracellular oscillations has emerged, and we find that B6A4C1 cells exhibit severely attenuated Ca(2+) oscillations in response to antigen, which are restored to wild-type RBL-2H3 levels by expression of constitutively active Cdc42 G12V or by a GEF for Cdc42, DOCK7, but not when the C-terminal di-arginine motif of active Cdc42 is mutated to di-glutamine. We found that antigen-stimulated FcεRI endocytosis, which occurs independently of Ca(2+) mobilization, is also defective in B6A4C1 cells, and Cdc42 G12V reconstitutes this response as well. Thus, activation of Cdc42 occurs prior to and is critical for antigen-stimulated pathways leading separately to both Ca(2+) mobilization and receptor endocytosis. Accounting for these downstream functional consequences, we show that Cdc42 G12V reconstitutes antigen-stimulated oscillations of phosphatidylinositol 4,5-bisphosphate (PIP2) at the plasma membrane in mutant B6A4C1 cells, pointing to Cdc42 participation in the regulation of stimulated PIP2 synthesis."xsd:string |
| http://purl.uniprot.org/citations/24996924 | http://purl.org/dc/terms/identifier | "doi:10.1242/bio.20148862"xsd:string |
| http://purl.uniprot.org/citations/24996924 | http://purl.uniprot.org/core/author | "Wilson J.D."xsd:string |
| http://purl.uniprot.org/citations/24996924 | http://purl.uniprot.org/core/author | "Baird B."xsd:string |
| http://purl.uniprot.org/citations/24996924 | http://purl.uniprot.org/core/author | "Holowka D."xsd:string |
| http://purl.uniprot.org/citations/24996924 | http://purl.uniprot.org/core/author | "Wilkes M.M."xsd:string |
| http://purl.uniprot.org/citations/24996924 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24996924 | http://purl.uniprot.org/core/name | "Biol Open"xsd:string |
| http://purl.uniprot.org/citations/24996924 | http://purl.uniprot.org/core/pages | "700-710"xsd:string |
| http://purl.uniprot.org/citations/24996924 | http://purl.uniprot.org/core/title | "Activation of Cdc42 is necessary for sustained oscillations of Ca2+ and PIP2 stimulated by antigen in RBL mast cells."xsd:string |
| http://purl.uniprot.org/citations/24996924 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/24996924 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24996924 |
| http://purl.uniprot.org/citations/24996924 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24996924 |
| http://purl.uniprot.org/uniprot/#_P52735-mappedCitation-24996924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24996924 |
| http://purl.uniprot.org/uniprot/#_Q15052-mappedCitation-24996924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24996924 |
| http://purl.uniprot.org/uniprot/#_A1L390-mappedCitation-24996924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24996924 |
| http://purl.uniprot.org/uniprot/#_O15085-mappedCitation-24996924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24996924 |
| http://purl.uniprot.org/uniprot/#_Q12979-mappedCitation-24996924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24996924 |
| http://purl.uniprot.org/uniprot/#_Q13009-mappedCitation-24996924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24996924 |
| http://purl.uniprot.org/uniprot/#_O75962-mappedCitation-24996924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24996924 |
| http://purl.uniprot.org/uniprot/#_Q15811-mappedCitation-24996924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24996924 |
| http://purl.uniprot.org/uniprot/#_O43307-mappedCitation-24996924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24996924 |
| http://purl.uniprot.org/uniprot/#_Q14344-mappedCitation-24996924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24996924 |
| http://purl.uniprot.org/uniprot/#_Q5JSL3-mappedCitation-24996924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24996924 |