| http://purl.uniprot.org/citations/24998521 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24998521 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24998521 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondrial morphology is regulated by conserved proteins involved in fusion and fission processes. The mammalian Optic atrophy 1 (OPA1) that functions in mitochondrial fusion is associated with Optic Atrophy and has been implicated in inner membrane cristae remodeling during cell death. Here, we show Drosophila Optic atrophy 1-like (Opa1-like) influences mitochondrial morphology through interaction with 'mitochondria-shaping' proteins like Mitochondrial assembly regulatory factor (Marf) and Drosophila Mitofilin (dMitofilin). To gain an insight into Opa1-like's network, we delineated bonafide interactors like dMitofilin, Marf, Serine protease High temperature requirement protein A2 (HTRA2), Rhomboid-7 (Rho-7) along with novel interactors such as Mortalin ortholog (Hsc70-5) from Drosophila mitochondrial extract. Interestingly, RNAi mediated down-regulation of hsc70-5 in Drosophila wing imaginal disc's peripodial cells resulted in fragmented mitochondria with reduced membrane potential leading to proteolysis of Opa1-like. Increased ecdysone activity induced dysfunctional fragmented mitochondria for clearance through lysosomes, an effect enhanced in hsc70-5 RNAi leading to increased cell death. Over-expression of Opa1-like rescues mitochondrial morphology and cell death in prepupal tissues expressing hsc70-5 RNAi. Taken together, we have identified a novel interaction between Hsc70-5/Mortalin and Opa1-like that influences cellular homeostasis through mitochondrial fusion."xsd:string |
| http://purl.uniprot.org/citations/24998521 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biocel.2014.05.041"xsd:string |
| http://purl.uniprot.org/citations/24998521 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biocel.2014.05.041"xsd:string |
| http://purl.uniprot.org/citations/24998521 | http://purl.uniprot.org/core/author | "Banerjee S."xsd:string |
| http://purl.uniprot.org/citations/24998521 | http://purl.uniprot.org/core/author | "Banerjee S."xsd:string |
| http://purl.uniprot.org/citations/24998521 | http://purl.uniprot.org/core/author | "Chinthapalli B."xsd:string |
| http://purl.uniprot.org/citations/24998521 | http://purl.uniprot.org/core/author | "Chinthapalli B."xsd:string |
| http://purl.uniprot.org/citations/24998521 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24998521 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24998521 | http://purl.uniprot.org/core/name | "Int. J. Biochem. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/24998521 | http://purl.uniprot.org/core/name | "Int. J. Biochem. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/24998521 | http://purl.uniprot.org/core/pages | "36-48"xsd:string |
| http://purl.uniprot.org/citations/24998521 | http://purl.uniprot.org/core/pages | "36-48"xsd:string |
| http://purl.uniprot.org/citations/24998521 | http://purl.uniprot.org/core/title | "A proteomic screen with Drosophila Opa1-like identifies Hsc70-5/Mortalin as a regulator of mitochondrial morphology and cellular homeostasis."xsd:string |
| http://purl.uniprot.org/citations/24998521 | http://purl.uniprot.org/core/title | "A proteomic screen with Drosophila Opa1-like identifies Hsc70-5/Mortalin as a regulator of mitochondrial morphology and cellular homeostasis."xsd:string |
| http://purl.uniprot.org/citations/24998521 | http://purl.uniprot.org/core/volume | "54"xsd:string |
| http://purl.uniprot.org/citations/24998521 | http://purl.uniprot.org/core/volume | "54"xsd:string |
| http://purl.uniprot.org/citations/24998521 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24998521 |
| http://purl.uniprot.org/citations/24998521 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24998521 |
| http://purl.uniprot.org/citations/24998521 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24998521 |
| http://purl.uniprot.org/citations/24998521 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24998521 |
| http://purl.uniprot.org/uniprot/P91928 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/24998521 |
| http://purl.uniprot.org/uniprot/P29845#attribution-1BEBCCA4E7DDA53A269F71D770377E62 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24998521 |