| http://purl.uniprot.org/citations/24999042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24999042 | http://www.w3.org/2000/01/rdf-schema#comment | "Granzyme B (GrzB) is expressed by activated T cells and mediates cellular apoptosis. GrzB also acts as an extracellular protease involved in tissue degradation. We hypothesized that GrzB production from activated memory CD4 T cells may be associated with HIV pathogenesis. We found that stimulated memory CD4 T cells (via costimulation, cytokines, and TLR ligands) concomitantly produced GrzB and HIV. Both GrzB and HIV expression were mainly restricted to CCR5-expressing memory CD4+CD45RO+ T cells, including Th1 and Th17 subsets. Activated memory CD4 T cells also mediated tissue damage, such as disruption of intestinal epithelial monolayers. In non-human primates, CD4 T cells of rhesus macaques (pathogenic SIV hosts) expressed higher GrzB compared to African green monkeys (non-pathogenic SIV hosts). These results suggest that GrzB from CCR5+ memory CD4 T cells may have a role in cellular and tissue pathologies during HIV infection."xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2014.06.008"xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/author | "Lin L."xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/author | "Nguyen C."xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/author | "Couturier J."xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/author | "Lewis D.E."xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/author | "Kimata J.T."xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/author | "Kozinetz C.A."xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/author | "Urvil P."xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/author | "Schmitz J.E."xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/author | "Medina M.A."xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/author | "Gingaras C."xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/author | "Savidge T.C."xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/author | "Hutchison A.T."xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/author | "Mahale P."xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/pages | "175-188"xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/title | "HIV replication in conjunction with granzyme B production by CCR5+ memory CD4 T cells: Implications for bystander cell and tissue pathologies."xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://purl.uniprot.org/core/volume | "462-463"xsd:string |
| http://purl.uniprot.org/citations/24999042 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24999042 |
| http://purl.uniprot.org/citations/24999042 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24999042 |
| http://purl.uniprot.org/uniprot/#_P10144-mappedCitation-24999042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24999042 |