| http://purl.uniprot.org/citations/25000897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25000897 | http://www.w3.org/2000/01/rdf-schema#comment | "Most organisms exhibit senescence; a decline in physiological function with age. In nature, rates of senescence vary extensively among individuals and this variation has a significant genetic component; however, we know little about the genes underlying senescence. Here we show the first evidence that individual alleles influence fecundity in an age-specific manner and so the genetic basis of natural variation in fecundity changes dramatically with age. We complete a genome-wide association to identify single-nucleotide polymorphisms (SNPs) affecting lifespan and age-specific fecundity using the Drosophila melanogaster Genetic Reference Panel. We identify 1,031 SNPs affecting fecundity and 52 influencing lifespan. Only one SNP is associated with both early- and late-age fecundity. The age-specific effect of candidate genes on fecundity is validated using RNA interference. In addition, there is a dramatic increase in the number of SNPs influencing fecundity with age. This result provides support for the mutation accumulation theory of aging."xsd:string |
| http://purl.uniprot.org/citations/25000897 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms5338"xsd:string |
| http://purl.uniprot.org/citations/25000897 | http://purl.uniprot.org/core/author | "Stone E.A."xsd:string |
| http://purl.uniprot.org/citations/25000897 | http://purl.uniprot.org/core/author | "Leips J."xsd:string |
| http://purl.uniprot.org/citations/25000897 | http://purl.uniprot.org/core/author | "Magwire M.M."xsd:string |
| http://purl.uniprot.org/citations/25000897 | http://purl.uniprot.org/core/author | "Durham M.F."xsd:string |
| http://purl.uniprot.org/citations/25000897 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25000897 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/25000897 | http://purl.uniprot.org/core/pages | "4338"xsd:string |
| http://purl.uniprot.org/citations/25000897 | http://purl.uniprot.org/core/title | "Genome-wide analysis in Drosophila reveals age-specific effects of SNPs on fitness traits."xsd:string |
| http://purl.uniprot.org/citations/25000897 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/25000897 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25000897 |
| http://purl.uniprot.org/citations/25000897 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25000897 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFF4-mappedCitation-25000897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25000897 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFF6-mappedCitation-25000897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25000897 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFN3-mappedCitation-25000897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25000897 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFQ2-mappedCitation-25000897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25000897 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFX7-mappedCitation-25000897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25000897 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFX8-mappedCitation-25000897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25000897 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFY8-mappedCitation-25000897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25000897 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHI3-mappedCitation-25000897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25000897 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHK1-mappedCitation-25000897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25000897 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHN3-mappedCitation-25000897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25000897 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHN4-mappedCitation-25000897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25000897 |