| http://purl.uniprot.org/citations/25002144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25002144 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulation of cell growth by nutrients is governed by highly conserved signaling pathways, yet mechanisms of nutrient sensing are still poorly understood. In yeast, glucose activates both the Ras/PKA pathway and TORC1, which coordinately regulate growth through enhancing translation and ribosome biogenesis and suppressing autophagy. Here, we show that cytosolic pH acts as a cellular signal to activate Ras and TORC1 in response to glucose availability. We demonstrate that cytosolic pH is sensitive to the quality and quantity of the available carbon source (C-source). Interestingly, Ras/PKA and TORC1 are both activated through the vacuolar ATPase (V-ATPase), which was previously identified as a sensor for cytosolic pH in vivo. V-ATPase interacts with two distinct GTPases, Arf1 and Gtr1, which are required for Ras and TORC1 activation, respectively. Together, these data provide a molecular mechanism for how cytosolic pH links C-source availability to the activity of signaling networks promoting cell growth."xsd:string |
| http://purl.uniprot.org/citations/25002144 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2014.06.002"xsd:string |
| http://purl.uniprot.org/citations/25002144 | http://purl.uniprot.org/core/author | "Peter M."xsd:string |
| http://purl.uniprot.org/citations/25002144 | http://purl.uniprot.org/core/author | "Saad S."xsd:string |
| http://purl.uniprot.org/citations/25002144 | http://purl.uniprot.org/core/author | "Ibanez A.J."xsd:string |
| http://purl.uniprot.org/citations/25002144 | http://purl.uniprot.org/core/author | "Dechant R."xsd:string |
| http://purl.uniprot.org/citations/25002144 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25002144 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/25002144 | http://purl.uniprot.org/core/pages | "409-421"xsd:string |
| http://purl.uniprot.org/citations/25002144 | http://purl.uniprot.org/core/title | "Cytosolic pH regulates cell growth through distinct GTPases, Arf1 and Gtr1, to promote Ras/PKA and TORC1 activity."xsd:string |
| http://purl.uniprot.org/citations/25002144 | http://purl.uniprot.org/core/volume | "55"xsd:string |
| http://purl.uniprot.org/citations/25002144 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25002144 |
| http://purl.uniprot.org/citations/25002144 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25002144 |
| http://purl.uniprot.org/uniprot/#_P11076-mappedCitation-25002144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25002144 |
| http://purl.uniprot.org/uniprot/#_A0A8U0WNW0-mappedCitation-25002144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25002144 |
| http://purl.uniprot.org/uniprot/#_A0A6A5Q0M1-mappedCitation-25002144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25002144 |
| http://purl.uniprot.org/uniprot/#_P37296-mappedCitation-25002144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25002144 |
| http://purl.uniprot.org/uniprot/#_P39923-mappedCitation-25002144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25002144 |
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| http://purl.uniprot.org/uniprot/#_P11792-mappedCitation-25002144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25002144 |
| http://purl.uniprot.org/uniprot/#_P16140-mappedCitation-25002144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25002144 |
| http://purl.uniprot.org/uniprot/#_Q00582-mappedCitation-25002144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25002144 |
| http://purl.uniprot.org/uniprot/#_P19146-mappedCitation-25002144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25002144 |
| http://purl.uniprot.org/uniprot/#_P32563-mappedCitation-25002144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25002144 |