| http://purl.uniprot.org/citations/25002492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25002492 | http://www.w3.org/2000/01/rdf-schema#comment | "The hematopoietic system declines with age. Myeloid-biased differentiation and increased incidence of myeloid malignancies feature aging of hematopoietic stem cells (HSCs), but the mechanisms involved remain uncertain. Here, we report that 4-mo-old mice deleted for transcription intermediary factor 1γ (Tif1γ) in HSCs developed an accelerated aging phenotype. To reinforce this result, we also show that Tif1γ is down-regulated in HSCs during aging in 20-mo-old wild-type mice. We established that Tif1γ controls TGF-β1 receptor (Tgfbr1) turnover. Compared with young HSCs, Tif1γ(-/-) and old HSCs are more sensitive to TGF-β signaling. Importantly, we identified two populations of HSCs specifically discriminated by Tgfbr1 expression level and provided evidence of the capture of myeloid-biased (Tgfbr1(hi)) and myeloid-lymphoid-balanced (Tgfbr1(lo)) HSCs. In conclusion, our data provide a new paradigm for Tif1γ in regulating the balance between lymphoid- and myeloid-derived HSCs through TGF-β signaling, leading to HSC aging."xsd:string |
| http://purl.uniprot.org/citations/25002492 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1405546111"xsd:string |
| http://purl.uniprot.org/citations/25002492 | http://purl.uniprot.org/core/author | "Pais de Barros J.P."xsd:string |
| http://purl.uniprot.org/citations/25002492 | http://purl.uniprot.org/core/author | "Delva L."xsd:string |
| http://purl.uniprot.org/citations/25002492 | http://purl.uniprot.org/core/author | "Hammann A."xsd:string |
| http://purl.uniprot.org/citations/25002492 | http://purl.uniprot.org/core/author | "Carmignac V."xsd:string |
| http://purl.uniprot.org/citations/25002492 | http://purl.uniprot.org/core/author | "Quere R."xsd:string |
| http://purl.uniprot.org/citations/25002492 | http://purl.uniprot.org/core/author | "Bastie J.N."xsd:string |
| http://purl.uniprot.org/citations/25002492 | http://purl.uniprot.org/core/author | "Largeot A."xsd:string |
| http://purl.uniprot.org/citations/25002492 | http://purl.uniprot.org/core/author | "Martin R.Z."xsd:string |
| http://purl.uniprot.org/citations/25002492 | http://purl.uniprot.org/core/author | "Chretien M.L."xsd:string |
| http://purl.uniprot.org/citations/25002492 | http://purl.uniprot.org/core/author | "Saint-Paul L."xsd:string |
| http://purl.uniprot.org/citations/25002492 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25002492 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/25002492 | http://purl.uniprot.org/core/pages | "10592-10597"xsd:string |
| http://purl.uniprot.org/citations/25002492 | http://purl.uniprot.org/core/title | "Tif1gamma regulates the TGF-beta1 receptor and promotes physiological aging of hematopoietic stem cells."xsd:string |
| http://purl.uniprot.org/citations/25002492 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/25002492 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25002492 |
| http://purl.uniprot.org/citations/25002492 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25002492 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JE09-mappedCitation-25002492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25002492 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGY5-mappedCitation-25002492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25002492 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFC3-mappedCitation-25002492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25002492 |
| http://purl.uniprot.org/uniprot/#_E9QME5-mappedCitation-25002492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25002492 |
| http://purl.uniprot.org/uniprot/#_E9QP19-mappedCitation-25002492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25002492 |