| http://purl.uniprot.org/citations/2500284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2500284 | http://www.w3.org/2000/01/rdf-schema#comment | "Genes that encode 3rd instar larval cuticle proteins (LCP's) of Drosophila melanogaster are located in at least two chromosomal sites. The genes encoding four of the five predominant LCP's are located in a cluster at the chromosomal region 44D. They are organized in pairs that are transcribed divergently, and expressed with different timing during the third larval instar. Towards understanding the basis of gene regulation within the 44D cluster, we have analyzed genetic variants, including the 2-3 variant, which has an insertion of a copia-like transposable element, H.M.S. Beagle, within the 44D cluster. The Beagle element appears to inactivate the LCP-3 gene by inserting into its TATA box, but also may cause the precocious expression of two other LCP genes, LCP-1 and LCP-f2, in the cluster. The long terminal repeat (LTR) of the Beagle element apparently contains a sequence, perhaps an enhancer-like element, which causes altered expression of these genes. We have also investigated the cis-regulatory elements involved in expression of the LCP-2 gene in wild-type larvae. We have identified two upstream regions that may contain separate cis-regulatory elements. The region between -252 bp and -515 bp may be essential for any expression of LCP-2. Additionally, the region between -515 bp and -795 bp appears to be required for the normal level of expression of the LCP-2 gene."xsd:string |
| http://purl.uniprot.org/citations/2500284 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvg.1020100309"xsd:string |
| http://purl.uniprot.org/citations/2500284 | http://purl.uniprot.org/core/author | "Alexander S."xsd:string |
| http://purl.uniprot.org/citations/2500284 | http://purl.uniprot.org/core/author | "Kimbrell D.A."xsd:string |
| http://purl.uniprot.org/citations/2500284 | http://purl.uniprot.org/core/author | "Tobin S.L."xsd:string |
| http://purl.uniprot.org/citations/2500284 | http://purl.uniprot.org/core/author | "Fristrom J.W."xsd:string |
| http://purl.uniprot.org/citations/2500284 | http://purl.uniprot.org/core/author | "Brown E.E."xsd:string |
| http://purl.uniprot.org/citations/2500284 | http://purl.uniprot.org/core/author | "Tojo S.J."xsd:string |
| http://purl.uniprot.org/citations/2500284 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2500284 | http://purl.uniprot.org/core/name | "Dev Genet"xsd:string |
| http://purl.uniprot.org/citations/2500284 | http://purl.uniprot.org/core/pages | "198-209"xsd:string |
| http://purl.uniprot.org/citations/2500284 | http://purl.uniprot.org/core/title | "Regulation of larval cuticle protein gene expression in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/2500284 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/2500284 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2500284 |
| http://purl.uniprot.org/citations/2500284 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2500284 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEM6-mappedCitation-2500284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2500284 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KF10-mappedCitation-2500284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2500284 |
| http://purl.uniprot.org/uniprot/#_P10351-mappedCitation-2500284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2500284 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEF3-mappedCitation-2500284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2500284 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEG7-mappedCitation-2500284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2500284 |
| http://purl.uniprot.org/uniprot/#_C0HL62-mappedCitation-2500284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2500284 |
| http://purl.uniprot.org/uniprot/#_C0HL63-mappedCitation-2500284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2500284 |
| http://purl.uniprot.org/uniprot/#_P02839-mappedCitation-2500284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2500284 |
| http://purl.uniprot.org/uniprot/#_P07187-mappedCitation-2500284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2500284 |