| http://purl.uniprot.org/citations/25006165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25006165 | http://www.w3.org/2000/01/rdf-schema#comment | "Kinetochores, multi-subunit complexes that assemble at the interface with centromeres, bind spindle microtubules to ensure faithful delivery of chromosomes during cell division. The configuration and function of the kinetochore-centromere interface is poorly understood. We report that a protein at this interface, CENP-M, is structurally and evolutionarily related to small GTPases but is incapable of GTP-binding and conformational switching. We show that CENP-M is crucially required for the assembly and stability of a tetramer also comprising CENP-I, CENP-H, and CENP-K, the HIKM complex, which we extensively characterize through a combination of structural, biochemical, and cell biological approaches. A point mutant affecting the CENP-M/CENP-I interaction hampers kinetochore assembly and chromosome alignment and prevents kinetochore recruitment of the CENP-T/W complex, questioning a role of CENP-T/W as founder of an independent axis of kinetochore assembly. Our studies identify a single pathway having CENP-C as founder, and CENP-H/I/K/M and CENP-T/W as CENP-C-dependent followers.DOI: http://dx.doi.org/10.7554/eLife.02978.001."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.02978"xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/author | "Valencia A."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/author | "Voss B."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/author | "Raunser S."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/author | "Vetter I.R."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/author | "De Antoni A."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/author | "Musacchio A."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/author | "Herzog F."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/author | "Pasqualato S."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/author | "Jeganathan S."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/author | "Massimiliano L."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/author | "Rojas A.M."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/author | "Krenn V."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/author | "Basilico F."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/author | "Weir J.R."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/author | "van Gerwen S."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/author | "Maffini S."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/author | "Zimniak T."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/author | "Prumbaum D."xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/pages | "e02978"xsd:string |
| http://purl.uniprot.org/citations/25006165 | http://purl.uniprot.org/core/title | "The pseudo GTPase CENP-M drives human kinetochore assembly."xsd:string |