| http://purl.uniprot.org/citations/25007834 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25007834 | http://www.w3.org/2000/01/rdf-schema#comment | "The abnormal growth of vascular smooth muscle cells (VSMCs) is considered a critical pathogenic process in inflammatory vascular diseases. We have previously demonstrated that protein phosphatase 2 A (PP2A)-mediated NF-κB dephosphorylation contributes to the anti-inflammatory properties of andrographolide, a novel NF-κB inhibitor. In this study, we investigated whether andrographolide causes apoptosis, and characterized its apoptotic mechanisms in rat VSMCs. Andrographolide activated the p38 mitogen-activated protein kinase (p38MAPK), leading to p53 phosphorylation. Phosphorylated p53 subsequently transactivated the expression of Bax, a pro-apoptotic protein. Transfection with pp2a small interfering RNA (siRNA) suppressed andrographolide-induced p38MAPK activation, p53 phosphorylation, and caspase 3 activation. Andrographolide also activated the Src homology 1 domain-containing protein tyrosine phosphatase (SHP-1), and induced PP2A dephosphorylation, both of which were inhibited by the SHP-1 inhibitor sodium stibogluconate (SSG) or shp-1 siRNA. SSG or shp-1 siRNA prevented andrographolide-induced apoptosis. These results suggest that andrographolide activates the PP2A-p38MAPK-p53-Bax cascade, causing mitochondrial dysfunction and VSMC death through an SHP-1-dependent mechanism."xsd:string |
| http://purl.uniprot.org/citations/25007834 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep05651"xsd:string |
| http://purl.uniprot.org/citations/25007834 | http://purl.uniprot.org/core/author | "Chen Y.Y."xsd:string |
| http://purl.uniprot.org/citations/25007834 | http://purl.uniprot.org/core/author | "Lin K.H."xsd:string |
| http://purl.uniprot.org/citations/25007834 | http://purl.uniprot.org/core/author | "Hsu M.J."xsd:string |
| http://purl.uniprot.org/citations/25007834 | http://purl.uniprot.org/core/author | "Hsieh C.Y."xsd:string |
| http://purl.uniprot.org/citations/25007834 | http://purl.uniprot.org/core/author | "Lu W.J."xsd:string |
| http://purl.uniprot.org/citations/25007834 | http://purl.uniprot.org/core/author | "Sheu J.R."xsd:string |
| http://purl.uniprot.org/citations/25007834 | http://purl.uniprot.org/core/author | "Chou D.S."xsd:string |
| http://purl.uniprot.org/citations/25007834 | http://purl.uniprot.org/core/author | "Jayakumar T."xsd:string |
| http://purl.uniprot.org/citations/25007834 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25007834 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/25007834 | http://purl.uniprot.org/core/pages | "5651"xsd:string |
| http://purl.uniprot.org/citations/25007834 | http://purl.uniprot.org/core/title | "Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade."xsd:string |
| http://purl.uniprot.org/citations/25007834 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/25007834 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25007834 |
| http://purl.uniprot.org/citations/25007834 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25007834 |
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| http://purl.uniprot.org/uniprot/#_P62716-mappedCitation-25007834 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25007834 |
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| http://purl.uniprot.org/uniprot/#_P63331-mappedCitation-25007834 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25007834 |