| http://purl.uniprot.org/citations/25008211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25008211 | http://www.w3.org/2000/01/rdf-schema#comment | "Proteins with N-terminal targeting signals are transported across the inner mitochondrial membrane by the presequence translocase. To drive precursor translocation, the Hsp70-import motor associates with the protein-conducting channel of the TIM23 complex. It is unknown how the ATPase cycle of Hsp70 is regulated in the context of a translocating polypeptide chain. Here we establish an assay to monitor protein dynamics in the precursor-occupied presequence translocase and find that regulatory subunits of the import motor, such as the ATPase-stimulating J-protein Pam18, are recruited into the translocation intermediate. The presence of all Hsp70 co-chaperones at the import channel is not sufficient to promote matrix protein import, instead a recharging of the active translocase with Pam18 is required for motor activity. Thus, a replenishment cycle of co-chaperones at the TIM23 complex is an integral part of Hsp70's ATPase cycle at the channel exit site and essential to maintain motor-driven mitochondrial protein import."xsd:string |
| http://purl.uniprot.org/citations/25008211 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms5349"xsd:string |
| http://purl.uniprot.org/citations/25008211 | http://purl.uniprot.org/core/author | "Rehling P."xsd:string |
| http://purl.uniprot.org/citations/25008211 | http://purl.uniprot.org/core/author | "Schulz C."xsd:string |
| http://purl.uniprot.org/citations/25008211 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25008211 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/25008211 | http://purl.uniprot.org/core/pages | "4349"xsd:string |
| http://purl.uniprot.org/citations/25008211 | http://purl.uniprot.org/core/title | "Remodelling of the active presequence translocase drives motor-dependent mitochondrial protein translocation."xsd:string |
| http://purl.uniprot.org/citations/25008211 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/25008211 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25008211 |
| http://purl.uniprot.org/citations/25008211 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25008211 |
| http://purl.uniprot.org/uniprot/#_Q07914-mappedCitation-25008211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25008211 |
| http://purl.uniprot.org/uniprot/#_P39515-mappedCitation-25008211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25008211 |
| http://purl.uniprot.org/uniprot/#_P0CS90-mappedCitation-25008211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25008211 |
| http://purl.uniprot.org/uniprot/#_P42949-mappedCitation-25008211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25008211 |
| http://purl.uniprot.org/uniprot/#_Q01852-mappedCitation-25008211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25008211 |
| http://purl.uniprot.org/uniprot/#_P47045-mappedCitation-25008211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25008211 |
| http://purl.uniprot.org/uniprot/#_P23644-mappedCitation-25008211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25008211 |
| http://purl.uniprot.org/uniprot/#_P32897-mappedCitation-25008211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25008211 |
| http://purl.uniprot.org/uniprot/#_P35180-mappedCitation-25008211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25008211 |
| http://purl.uniprot.org/uniprot/#_P36147-mappedCitation-25008211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25008211 |
| http://purl.uniprot.org/uniprot/#_P53220-mappedCitation-25008211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25008211 |
| http://purl.uniprot.org/uniprot/#_Q02776-mappedCitation-25008211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25008211 |
| http://purl.uniprot.org/uniprot/#_Q02889-mappedCitation-25008211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25008211 |