| http://purl.uniprot.org/citations/25008864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25008864 | http://www.w3.org/2000/01/rdf-schema#comment | "The major histocompatibility complex (MHC) region on chromosome 6p21.3 is suspected to host susceptibility loci for HIV-related Kaposi's sarcoma (HIV-KS). A nested case-control study in the Multicenter AIDS Cohort Study was designed to conduct fine genetic association mapping across central MHC. Individuals co-infected with HIV-1 and human herpes virus-8 who later developed KS were defined as cases (n=354) and were matched 1:1 with co-infected KS-free controls. We report data for new independent MHC class II and III susceptibility loci. In particular, class II HLA-DMB emerged as a strong candidate, with the intronic variant rs6902982 A>G associated with a fourfold increase of risk (odds ratio (OR)=4.09; 95% confidence interval (CI)=1.90-8.80; P=0.0003). A striking multiplicative effect on the estimated risk was associated with further carriage of two non-synonymous variants, rs1800453 A>G (Asp697Gly) and rs4148880 A>G (Ile393Val), in the linked TAP1 gene (OR=10.5; 95% CI=2.54-43.6; P=0.0012). The class III susceptibility variant is moderately associated with HIV-KS and lies within a 120-kb-long haplotype (OR=1.52; 95% CI=1.01-2.28; P=0.047) formed by rs7029 A>G (GPANK1 3' untranslated region), rs1065356 G>A (LY6G6C), rs3749953 A>G (MSH5-SAPCD1 read through) and rs707926 G>A (VARS). Our data suggest that antigen processing by MHC class II molecules is a target pathway in the pathogenesis of HIV-KS."xsd:string |
| http://purl.uniprot.org/citations/25008864 | http://purl.org/dc/terms/identifier | "doi:10.1038/gene.2014.42"xsd:string |
| http://purl.uniprot.org/citations/25008864 | http://purl.uniprot.org/core/author | "Shrestha S."xsd:string |
| http://purl.uniprot.org/citations/25008864 | http://purl.uniprot.org/core/author | "Kaslow R.A."xsd:string |
| http://purl.uniprot.org/citations/25008864 | http://purl.uniprot.org/core/author | "Jacobson L.P."xsd:string |
| http://purl.uniprot.org/citations/25008864 | http://purl.uniprot.org/core/author | "Wiener H.W."xsd:string |
| http://purl.uniprot.org/citations/25008864 | http://purl.uniprot.org/core/author | "Aissani B."xsd:string |
| http://purl.uniprot.org/citations/25008864 | http://purl.uniprot.org/core/author | "Boehme A.K."xsd:string |
| http://purl.uniprot.org/citations/25008864 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25008864 | http://purl.uniprot.org/core/name | "Genes Immun"xsd:string |
| http://purl.uniprot.org/citations/25008864 | http://purl.uniprot.org/core/pages | "424-429"xsd:string |
| http://purl.uniprot.org/citations/25008864 | http://purl.uniprot.org/core/title | "SNP screening of central MHC-identified HLA-DMB as a candidate susceptibility gene for HIV-related Kaposi's sarcoma."xsd:string |
| http://purl.uniprot.org/citations/25008864 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/25008864 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25008864 |
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