| http://purl.uniprot.org/citations/25009281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25009281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25009281 | http://www.w3.org/2000/01/rdf-schema#comment | "p120-catenin (p120) modulates adherens junction (AJ) dynamics by controlling the stability of classical cadherins. Among all p120 isoforms, p120-3A and p120-1A are the most prevalent. Both stabilize cadherins, but p120-3A is preferred in epithelia, whereas p120-1A takes precedence in neurons, fibroblasts, and macrophages. During epithelial-to-mesenchymal transition, E-to N-cadherin switching coincides with p120-3A to -1A alternative splicing. These isoforms differ by a 101-amino acid "head domain" comprising the p120-1A N-terminus. Although its exact role is unknown, the head domain likely mediates developmental and cancer-associated events linked to p120-1A expression (e.g., motility, invasion, metastasis). Here we identified delta-interacting protein A (DIPA) as the first head domain-specific binding partner and candidate mediator of isoform 1A activity. DIPA colocalizes with AJs in a p120-1A-but not 3A-dependent manner. Moreover, all DIPA family members (Ccdc85a, Ccdc85b/DIPA, and Ccdc85c) interact reciprocally with p120 family members (p120, δ-catenin, p0071, and ARVCF), suggesting significant functional overlap. During zebrafish neural tube development, both knockdown and overexpression of DIPA phenocopy N-cadherin mutations, an effect bearing functional ties to a reported mouse hydrocephalus phenotype associated with Ccdc85c. These studies identify a novel, highly conserved interaction between two protein families that may participate either individually or collectively in N-cadherin-mediated development."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e13-08-0492"xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e13-08-0492"xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/author | "Yu H."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/author | "Yu H."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/author | "Reynolds A.B."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/author | "Reynolds A.B."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/author | "Coffey R.J."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/author | "Coffey R.J."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/author | "Dohn M.R."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/author | "Dohn M.R."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/author | "Doll C.A."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/author | "Doll C.A."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/author | "Gamse J.T."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/author | "Gamse J.T."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/author | "Markham N.O."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/author | "Markham N.O."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/author | "McCrea P.D."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/author | "McCrea P.D."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/author | "Miller R.K."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/author | "Miller R.K."xsd:string |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25009281 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |