| http://purl.uniprot.org/citations/25010283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25010283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25010283 | http://www.w3.org/2000/01/rdf-schema#comment | "Classical swine fever virus (CSFV) Core protein is involved in virus RNA protection, transcription regulation and virus virulence. To discover additional Core protein functions a yeast two-hybrid system was used to identify host proteins that interact with Core. Among the identified host proteins, the osteosarcoma amplified 9 protein (OS9) was further studied. Using alanine scanning mutagenesis, the OS9 binding site in the CSFV Core protein was identified, between Core residues (90)IAIM(93), near a putative cleavage site. Truncated versions of Core were used to show that OS9 binds a polypeptide representing the 12 C-terminal Core residues. Cells transfected with a double-fluorescent labeled Core construct demonstrated that co-localization of OS9 and Core occurred only on unprocessed forms of Core protein. A recombinant CSFV containing Core protein where residues (90)IAIM(93) were substituted by alanines showed no altered virulence in swine, but a significant decreased ability to replicate in cell cultures."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2014.05.008"xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2014.05.008"xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "Carlson J."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "Carlson J."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "Borca M.V."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "Borca M.V."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "Lu Z."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "Lu Z."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "Gladue D.P."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "Gladue D.P."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "Holinka L.G."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "Holinka L.G."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "O'Donnell V."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "O'Donnell V."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "Fletcher P."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "Fletcher P."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "Baker-Branstetter R."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "Baker-Branstetter R."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "Fernandez-Sainz I.J."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "Fernandez-Sainz I.J."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "Sanford B."xsd:string |
| http://purl.uniprot.org/citations/25010283 | http://purl.uniprot.org/core/author | "Sanford B."xsd:string |