| http://purl.uniprot.org/citations/25012242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25012242 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuroblastoma, featured by a high rate of spontaneous remissions, is the most common extra-cranial solid tumor in infants and children. Numerous reports have demonstrated that MicroRNAs (miRNAs) play essential roles in cancer progression, including cell proliferation, apoptosis, invasion, metastasis and angiogenesis. miR-421 functions as an onco-miR in some malignancies. However, its role in neuroblastoma remains poorly understood. In the present study, we found that miR-421 was increased in neuroblastoma tissues compared with matched adjacent normal tissues. Forced overexpression of miR-421 substantially enhanced cell proliferation, cell-cycle progression, migration, and invasion of neuroblastoma cells. At the molecular level, tumor suppressor menin was found to be a target of miR-421. Furthermore, downregulation of menin by small interfering RNA oligos exhibited similar effects with overexpression of miR-421. On the other hand, overexpression of menin partially reversed the proliferative effects of miR-421 in neuroblastoma cells. Collectively, miR-421 may promote neuroblastoma cell growth and motility partially by targeting menin."xsd:string |
| http://purl.uniprot.org/citations/25012242 | http://purl.org/dc/terms/identifier | "doi:10.1007/s13277-014-1921-1"xsd:string |
| http://purl.uniprot.org/citations/25012242 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/25012242 | http://purl.uniprot.org/core/author | "Li Y.M."xsd:string |
| http://purl.uniprot.org/citations/25012242 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/25012242 | http://purl.uniprot.org/core/author | "Li H.Y."xsd:string |
| http://purl.uniprot.org/citations/25012242 | http://purl.uniprot.org/core/author | "Zhang J.G."xsd:string |
| http://purl.uniprot.org/citations/25012242 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25012242 | http://purl.uniprot.org/core/name | "Tumour Biol"xsd:string |
| http://purl.uniprot.org/citations/25012242 | http://purl.uniprot.org/core/pages | "10011-10017"xsd:string |
| http://purl.uniprot.org/citations/25012242 | http://purl.uniprot.org/core/title | "Downregulation of tumor suppressor menin by miR-421 promotes proliferation and migration of neuroblastoma."xsd:string |
| http://purl.uniprot.org/citations/25012242 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/25012242 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25012242 |
| http://purl.uniprot.org/citations/25012242 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25012242 |
| http://purl.uniprot.org/uniprot/#_C9DZM4-mappedCitation-25012242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25012242 |
| http://purl.uniprot.org/uniprot/#_G9G6R5-mappedCitation-25012242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25012242 |
| http://purl.uniprot.org/uniprot/#_O00255-mappedCitation-25012242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25012242 |
| http://purl.uniprot.org/uniprot/#_Q7Z6F9-mappedCitation-25012242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25012242 |
| http://purl.uniprot.org/uniprot/#_Q9GZQ5-mappedCitation-25012242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25012242 |
| http://purl.uniprot.org/uniprot/#_Q7Z5Y5-mappedCitation-25012242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25012242 |
| http://purl.uniprot.org/uniprot/#_Q9UE24-mappedCitation-25012242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25012242 |
| http://purl.uniprot.org/uniprot/O00255 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25012242 |
| http://purl.uniprot.org/uniprot/C9DZM4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25012242 |
| http://purl.uniprot.org/uniprot/Q7Z5Y5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25012242 |