| http://purl.uniprot.org/citations/25014715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25014715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25014715 | http://www.w3.org/2000/01/rdf-schema#comment | "The TenA protein family occurs in prokaryotes, plants and fungi; it has two subfamilies, one (TenA_C) having an active-site cysteine, the other (TenA_E) not. TenA_C proteins participate in thiamin salvage by hydrolysing the thiamin breakdown product amino-HMP (4-amino-5-aminomethyl-2-methylpyrimidine) to HMP (4-amino-5-hydroxymethyl-2-methylpyrimidine); the function of TenA_E proteins is unknown. Comparative analysis of prokaryote and plant genomes predicted that (i) TenA_E has a salvage role similar to, but not identical with, that of TenA_C and (ii) that TenA_E and TenA_C also have non-salvage roles since they occur in organisms that cannot make thiamin. Recombinant Arabidopsis and maize TenA_E proteins (At3g16990, GRMZM2G080501) hydrolysed amino-HMP to HMP and, far more actively, hydrolysed the N-formyl derivative of amino-HMP to amino-HMP. Ablating the At3g16990 gene in a line with a null mutation in the HMP biosynthesis gene ThiC prevented its rescue by amino-HMP. Ablating At3g16990 in the wild-type increased sensitivity to paraquat-induced oxidative stress; HMP overcame this increased sensitivity. Furthermore, the expression of TenA_E and ThiC genes in Arabidopsis and maize was inversely correlated. These results indicate that TenA_E proteins mediate amidohydrolase and aminohydrolase steps in the salvage of thiamin breakdown products. As such products can be toxic, TenA_E proteins may also pre-empt toxicity."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20140522"xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20140522"xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "Goyer A."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "Goyer A."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "Hanson A.D."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "Hanson A.D."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "Hunt J.F."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "Hunt J.F."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "Benach J."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "Benach J."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "McCarty D.R."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "McCarty D.R."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "Ziemak M.J."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "Ziemak M.J."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "de Crecy-Lagard V."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "de Crecy-Lagard V."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "Gerdes S."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "Gerdes S."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "Zallot R."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "Zallot R."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "Shintani D.K."xsd:string |
| http://purl.uniprot.org/citations/25014715 | http://purl.uniprot.org/core/author | "Shintani D.K."xsd:string |