| http://purl.uniprot.org/citations/25016018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25016018 | http://www.w3.org/2000/01/rdf-schema#comment | "β-Arrestins are signaling adaptors that bind to agonist-occupied G protein-coupled receptors (GPCRs) and target them for endocytosis; however, the mechanisms regulating receptor/β-arrestin complexes and trafficking in endosomes, remain ill defined. Here we show, in live cells, differential dynamic regulation of endosomal bradykinin B2 receptor (B2R) complexes with either β-arrestin-1 or -2. We find a novel role for MAPK in the B2R/β-arrestin-2 complex formation, receptor trafficking and signaling mediated by an ERK1/2 regulatory motif in the hinge domain of the rat β-arrestin-2 (PET(178)P), but not rat β-arrestin-1 (PER(177)P). While the ERK1/2 regulatory motif is conserved between rat and mouse β-arrestin-2, it is surprisingly not conserved in human β-arrestin-2 (PEK(178)P). However, mutation of lysine 178 to threonine is sufficient to confer MAPK sensitivity to the human β-arrestin-2. Furthermore, substitution for a phosphomimetic residue in both the rat and the human β-arrestin-2 (T/K178D) significantly stabilizes B2R/β-arrestin complexes in endosomes, delays receptor recycling to the plasma membrane and maintains intracellular MAPK signaling. Similarly, the endosomal trafficking of β2-adrenergic, angiotensin II type 1 and vasopressin V2 receptors was altered by the β-arrestin-2 T178D mutant. Our findings unveil a novel subtype specific mode of MAPK-dependent regulation of β-arrestins in intracellular trafficking and signaling of GPCRs, and suggest differential endosomal receptor/β-arrestin-2 signaling roles among species."xsd:string |
| http://purl.uniprot.org/citations/25016018 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.568147"xsd:string |
| http://purl.uniprot.org/citations/25016018 | http://purl.uniprot.org/core/author | "Laporte S.A."xsd:string |
| http://purl.uniprot.org/citations/25016018 | http://purl.uniprot.org/core/author | "Simaan M."xsd:string |
| http://purl.uniprot.org/citations/25016018 | http://purl.uniprot.org/core/author | "Namkung Y."xsd:string |
| http://purl.uniprot.org/citations/25016018 | http://purl.uniprot.org/core/author | "Khoury E."xsd:string |
| http://purl.uniprot.org/citations/25016018 | http://purl.uniprot.org/core/author | "Nikolajev L."xsd:string |
| http://purl.uniprot.org/citations/25016018 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25016018 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/25016018 | http://purl.uniprot.org/core/pages | "23302-23317"xsd:string |
| http://purl.uniprot.org/citations/25016018 | http://purl.uniprot.org/core/title | "Differential regulation of endosomal GPCR/beta-arrestin complexes and trafficking by MAPK."xsd:string |
| http://purl.uniprot.org/citations/25016018 | http://purl.uniprot.org/core/volume | "289"xsd:string |
| http://purl.uniprot.org/citations/25016018 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25016018 |
| http://purl.uniprot.org/citations/25016018 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25016018 |
| http://purl.uniprot.org/uniprot/P29066#attribution-593E29D6183E709D85FDCE94C4C1A62B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25016018 |
| http://purl.uniprot.org/uniprot/#_A0A8I6APG4-mappedCitation-25016018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25016018 |
| http://purl.uniprot.org/uniprot/#_A0A8I6G7K6-mappedCitation-25016018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25016018 |
| http://purl.uniprot.org/uniprot/#_A0A8I6GL31-mappedCitation-25016018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25016018 |
| http://purl.uniprot.org/uniprot/#_A0A8L2QE39-mappedCitation-25016018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25016018 |
| http://purl.uniprot.org/uniprot/#_A0A8L2QMJ8-mappedCitation-25016018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25016018 |
| http://purl.uniprot.org/uniprot/#_P29066-mappedCitation-25016018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25016018 |
| http://purl.uniprot.org/uniprot/#_P29067-mappedCitation-25016018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25016018 |
| http://purl.uniprot.org/uniprot/A0A8I6G7K6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25016018 |
| http://purl.uniprot.org/uniprot/P29067 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25016018 |