| http://purl.uniprot.org/citations/25026278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25026278 | http://www.w3.org/2000/01/rdf-schema#comment | "H-Prune hydrolyzes short-chain polyphosphates (PPase activity) together with an hitherto cAMP-phosphodiesterase (PDE), the latest influencing different human cancers by its overexpression. H-Prune promotes cell migration in cooperation with glycogen synthase kinase-3 (Gsk-3β). Gsk-3β is a negative regulator of canonical WNT/β-catenin signaling. Here, we investigate the role of Gsk-3β/h-Prune complex in the regulation of WNT/β-catenin signaling, demonstrating the h-Prune capability to activate WNT signaling also in a paracrine manner, through Wnt3a secretion. In vivo study demonstrates that h-Prune silencing inhibits lung metastasis formation, increasing mouse survival. We assessed h-Prune levels in peripheral blood of lung cancer patients using ELISA assay, showing that h-Prune is an early diagnostic marker for lung cancer. Our study dissects out the mechanism of action of h-Prune in tumorigenic cells and also sheds light on the identification of a new therapeutic target in non-small-cell lung cancer."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.2169"xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Freeman J."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Zollo M."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Bello A.M."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Fusco A."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Benvenuto G."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Dale T.C."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Federico A."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Carotenuto M."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Chiappetta G."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Liguori L."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Terracciano L."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Turino C."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Damiani V."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Vitiello F."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Pasquinelli R."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Attanasio C."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Calabrese C."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Decraene C."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "De Antonellis P."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Alonzi A."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Magliulo D."xsd:string |
| http://purl.uniprot.org/citations/25026278 | http://purl.uniprot.org/core/author | "Piantedosi F."xsd:string |