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| http://purl.uniprot.org/citations/25028513 | http://www.w3.org/2000/01/rdf-schema#comment | "Multiple system atrophy (MSA) is a neurodegenerative disease caused by α-synuclein aggregation in oligodendrocytes and neurons. Using a transgenic mouse model overexpressing human α-synuclein in oligodendrocytes, we previously demonstrated that oligodendrocytic α-synuclein inclusions induce neuronal α-synuclein accumulation and progressive neuronal degeneration. α-Synuclein binds to β-III tubulin, leading to the neuronal accumulation of insoluble α-synuclein in an MSA mouse model. The present study demonstrates that α-synuclein co-localizes with β-III tubulin in the brain tissue from patients with MSA and MSA model transgenic mice as well as neurons cultured from these mice. Accumulation of insoluble α-synuclein in MSA mouse neurons was blocked by the peptide fragment β-III tubulin (residues 235-282). We have determined the α-synuclein-binding domain of β-III tubulin and demonstrated that a short fragment containing this domain can suppress α-synuclein accumulation in the primary cultured cells. Administration of a short α-synuclein-binding fragment of β-III tubulin may be a novel therapeutic strategy for MSA."xsd:string |
| http://purl.uniprot.org/citations/25028513 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.557215"xsd:string |
| http://purl.uniprot.org/citations/25028513 | http://purl.uniprot.org/core/author | "Suzuki Y."xsd:string |
| http://purl.uniprot.org/citations/25028513 | http://purl.uniprot.org/core/author | "Jin C."xsd:string |
| http://purl.uniprot.org/citations/25028513 | http://purl.uniprot.org/core/author | "Yazawa I."xsd:string |
| http://purl.uniprot.org/citations/25028513 | http://purl.uniprot.org/core/author | "Iwase T."xsd:string |
| http://purl.uniprot.org/citations/25028513 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25028513 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/25028513 | http://purl.uniprot.org/core/pages | "24374-24382"xsd:string |
| http://purl.uniprot.org/citations/25028513 | http://purl.uniprot.org/core/title | "beta-III Tubulin fragments inhibit alpha-synuclein accumulation in models of multiple system atrophy."xsd:string |
| http://purl.uniprot.org/citations/25028513 | http://purl.uniprot.org/core/volume | "289"xsd:string |
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