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Background

Childhood obesity has become a global public health problem in recent years. This study aimed to explore the association of genetic variants in INSIG-SCAP-SREBP pathway with obesity in Chinese children.

Methods

A case-control study was conducted, including 705 obese cases and 1,325 nonobese controls. We genotyped 15 single nucleotide polymorphisms (SNPs) of five genes in INSIG-SCAP-SREBP pathway, including insulin induced gene 1 (INSIG1), insulin induced gene 2 (INSIG2), SREBP cleavage-activating protein gene (SCAP), sterol regulatory element binding protein gene 1 (SREBP1), and sterol regulatory element binding protein gene 2 (SREBP2). We used generalized multifactor dimensionality reduction (GMDR) and logistic regression to investigate gene-gene interactions.

Results

Single polymorphism analyses showed that SCAP rs12487736 and rs12490383 were nominally associated with obesity. We identified a 3-locus interaction on obesity in GMDR analyses (P = 0.001), involving 3 genetic variants of INSIG2, SCAP, and SREBP2. The individuals in high-risk group of the 3-locus combinations had a 79.9% increased risk of obesity compared with those in low-risk group (OR = 1.799, 95% CI: 1.475-2.193, P = 6.61 × 10(-9)).

Conclusion

We identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect."xsd:string
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http://purl.uniprot.org/citations/25028659http://purl.uniprot.org/core/author"Ma J."xsd:string
http://purl.uniprot.org/citations/25028659http://purl.uniprot.org/core/author"Song J.Y."xsd:string
http://purl.uniprot.org/citations/25028659http://purl.uniprot.org/core/author"Wang H.J."xsd:string
http://purl.uniprot.org/citations/25028659http://purl.uniprot.org/core/author"Liu F.H."xsd:string
http://purl.uniprot.org/citations/25028659http://purl.uniprot.org/core/author"Meng X.R."xsd:string
http://purl.uniprot.org/citations/25028659http://purl.uniprot.org/core/author"Shang X.R."xsd:string
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http://purl.uniprot.org/citations/25028659http://purl.uniprot.org/core/title"The gene-gene interaction of INSIG-SCAP-SREBP pathway on the risk of obesity in Chinese children."xsd:string
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