| http://purl.uniprot.org/citations/25030448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25030448 | http://www.w3.org/2000/01/rdf-schema#comment | "The US11 gene product of human cytomegalovirus promotes viral immune evasion by hijacking the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. US11 initiates dislocation of newly translocated MHC I from the ER to the cytosol for proteasome-mediated degradation. Despite the critical role for ubiquitin in this degradation pathway, the responsible E3 ligase is unknown. In a forward genetic screen for host ERAD components hijacked by US11 in near-haploid KBM7 cells, we identified TMEM129, an uncharacterized polytopic membrane protein. TMEM129 is essential and rate-limiting for US11-mediated MHC-I degradation and acts as a novel ER resident E3 ubiquitin ligase. TMEM129 contains an unusual cysteine-only RING with intrinsic E3 ligase activity and is recruited to US11 via Derlin-1. Together with its E2 conjugase Ube2J2, TMEM129 is responsible for the ubiquitination, dislocation, and subsequent degradation of US11-associated MHC-I. US11 engages two degradation pathways: a Derlin-1/TMEM129-dependent pathway required for MHC-I degradation and a SEL1L/HRD1-dependent pathway required for "free" US11 degradation. Our data show that TMEM129 is a novel ERAD E3 ligase and the central component of a novel mammalian ERAD complex."xsd:string |
| http://purl.uniprot.org/citations/25030448 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1409099111"xsd:string |
| http://purl.uniprot.org/citations/25030448 | http://purl.uniprot.org/core/author | "Dougan G."xsd:string |
| http://purl.uniprot.org/citations/25030448 | http://purl.uniprot.org/core/author | "Lehner P.J."xsd:string |
| http://purl.uniprot.org/citations/25030448 | http://purl.uniprot.org/core/author | "Nathan J.A."xsd:string |
| http://purl.uniprot.org/citations/25030448 | http://purl.uniprot.org/core/author | "Timms R.T."xsd:string |
| http://purl.uniprot.org/citations/25030448 | http://purl.uniprot.org/core/author | "Grice G.L."xsd:string |
| http://purl.uniprot.org/citations/25030448 | http://purl.uniprot.org/core/author | "Stagg H.R."xsd:string |
| http://purl.uniprot.org/citations/25030448 | http://purl.uniprot.org/core/author | "van den Boomen D.J."xsd:string |
| http://purl.uniprot.org/citations/25030448 | http://purl.uniprot.org/core/author | "Skodt K."xsd:string |
| http://purl.uniprot.org/citations/25030448 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25030448 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/25030448 | http://purl.uniprot.org/core/pages | "11425-11430"xsd:string |
| http://purl.uniprot.org/citations/25030448 | http://purl.uniprot.org/core/title | "TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I."xsd:string |
| http://purl.uniprot.org/citations/25030448 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/25030448 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25030448 |
| http://purl.uniprot.org/citations/25030448 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25030448 |
| http://purl.uniprot.org/uniprot/#_B2R979-mappedCitation-25030448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25030448 |
| http://purl.uniprot.org/uniprot/#_A0AVI4-mappedCitation-25030448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25030448 |
| http://purl.uniprot.org/uniprot/#_B4E1G1-mappedCitation-25030448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25030448 |
| http://purl.uniprot.org/uniprot/#_B4E1K4-mappedCitation-25030448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25030448 |
| http://purl.uniprot.org/uniprot/#_E5RGY0-mappedCitation-25030448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25030448 |
| http://purl.uniprot.org/uniprot/#_P0CG47-mappedCitation-25030448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25030448 |
| http://purl.uniprot.org/uniprot/#_P0CG48-mappedCitation-25030448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25030448 |