| http://purl.uniprot.org/citations/25031071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25031071 | http://www.w3.org/2000/01/rdf-schema#comment | "Karyopherin α2 (KPNA2) functions as an adaptor that transports several proteins to the nucleus. Emerging evidence suggests that KPNA2 plays a crucial role in oncogenesis and early recurrence. In the present study, we evaluated the expression pattern of KPNA2 in 221 hepatocellular carcinoma (HCC) specimens and matching adjacent, non-tumorous tissues (NT) by immunohistochemical assays. We found that nuclear KPNA2 expression was significantly upregulated (30.3 %, 67/221) in HCC tissues; however, no nuclear expression of KPNA2 in NT tissues was observed. A correlation analysis demonstrated that nuclear KPNA2 expression was positively associated with serum AFP level, tumor differentiation, vascular invasion, BCLC stage and early recurrence (all p < 0.05). Nuclear KPNA2 expression was associated with a poor prognosis in HCC patients. Univariate and multivariate analyses demonstrated that KPNA2 was an independent prognostic factor for both overall survival (p < 0.001) and time to recurrence (p < 0.001) in HCC patients. Furthermore, in a validation cohort, nuclear expression of KPNA2 was observed in 16 of 47 (34.0 %) small hepatocellular carcinoma patients. Importantly, the risk of recurrence associated with nuclear KPNA2 expression (9/16, 56.2 %) was significantly higher than the risk associated with an absence of nuclear KPNA2 expression (6/31, 19.3 %; p = 0.01). Our results demonstrate that nuclear KPNA2 expression is a poor prognostic biomarker for HCC, especially for early-stage HCC."xsd:string |
| http://purl.uniprot.org/citations/25031071 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12032-014-0131-4"xsd:string |
| http://purl.uniprot.org/citations/25031071 | http://purl.uniprot.org/core/author | "Jiang P."xsd:string |
| http://purl.uniprot.org/citations/25031071 | http://purl.uniprot.org/core/author | "Hong J."xsd:string |
| http://purl.uniprot.org/citations/25031071 | http://purl.uniprot.org/core/author | "Tang Y."xsd:string |
| http://purl.uniprot.org/citations/25031071 | http://purl.uniprot.org/core/author | "Tang H."xsd:string |
| http://purl.uniprot.org/citations/25031071 | http://purl.uniprot.org/core/author | "Hu L."xsd:string |
| http://purl.uniprot.org/citations/25031071 | http://purl.uniprot.org/core/author | "He L."xsd:string |
| http://purl.uniprot.org/citations/25031071 | http://purl.uniprot.org/core/author | "Liang M."xsd:string |
| http://purl.uniprot.org/citations/25031071 | http://purl.uniprot.org/core/author | "Mai C."xsd:string |
| http://purl.uniprot.org/citations/25031071 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25031071 | http://purl.uniprot.org/core/name | "Med Oncol"xsd:string |
| http://purl.uniprot.org/citations/25031071 | http://purl.uniprot.org/core/pages | "131"xsd:string |
| http://purl.uniprot.org/citations/25031071 | http://purl.uniprot.org/core/title | "Aberrant expression of nuclear KPNA2 is correlated with early recurrence and poor prognosis in patients with small hepatocellular carcinoma after hepatectomy."xsd:string |
| http://purl.uniprot.org/citations/25031071 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/25031071 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25031071 |
| http://purl.uniprot.org/citations/25031071 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25031071 |
| http://purl.uniprot.org/uniprot/#_A8K7D9-mappedCitation-25031071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25031071 |
| http://purl.uniprot.org/uniprot/#_P52292-mappedCitation-25031071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25031071 |
| http://purl.uniprot.org/uniprot/#_Q7Z726-mappedCitation-25031071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25031071 |
| http://purl.uniprot.org/uniprot/Q7Z726 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25031071 |
| http://purl.uniprot.org/uniprot/P52292 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25031071 |
| http://purl.uniprot.org/uniprot/A8K7D9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25031071 |