RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/25034023http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25034023http://www.w3.org/2000/01/rdf-schema#comment"Fibrillins form multifunctional microfibrils in most connective tissues. Deficiencies in fibrillin assembly can result in fibrillinopathies, such as Marfan syndrome. We demonstrate the presence of heparin/heparan sulfate binding sites in fibrillin-2 and -3. Multimerization of all three fibrillins drastically increased the apparent affinity of their interaction with heparin/heparan sulfate. Surprisingly, contrary to other reports heparin/heparan sulfate strongly inhibited homo- and heterotypic N-to-C-terminal fibrillin interactions. These data suggest that heparin/heparan sulfate controls the formation of microfibrils at the bead interaction stage."xsd:string
http://purl.uniprot.org/citations/25034023http://purl.org/dc/terms/identifier"doi:10.1016/j.febslet.2014.06.061"xsd:string
http://purl.uniprot.org/citations/25034023http://purl.uniprot.org/core/author"Sabatier L."xsd:string
http://purl.uniprot.org/citations/25034023http://purl.uniprot.org/core/author"Reinhardt D.P."xsd:string
http://purl.uniprot.org/citations/25034023http://purl.uniprot.org/core/author"Hubmacher D."xsd:string
http://purl.uniprot.org/citations/25034023http://purl.uniprot.org/core/author"Djokic J."xsd:string
http://purl.uniprot.org/citations/25034023http://purl.uniprot.org/core/author"Nelea V."xsd:string
http://purl.uniprot.org/citations/25034023http://purl.uniprot.org/core/author"Dzafik D."xsd:string
http://purl.uniprot.org/citations/25034023http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/25034023http://purl.uniprot.org/core/name"FEBS Lett"xsd:string
http://purl.uniprot.org/citations/25034023http://purl.uniprot.org/core/pages"2890-2897"xsd:string
http://purl.uniprot.org/citations/25034023http://purl.uniprot.org/core/title"Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly."xsd:string
http://purl.uniprot.org/citations/25034023http://purl.uniprot.org/core/volume"588"xsd:string
http://purl.uniprot.org/citations/25034023http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25034023
http://purl.uniprot.org/citations/25034023http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25034023
http://purl.uniprot.org/uniprot/P35555#attribution-A0FFC7EC48E22308CD5C2122E4E5FD24http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/25034023
http://purl.uniprot.org/uniprot/#_P02751-mappedCitation-25034023http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25034023
http://purl.uniprot.org/uniprot/#_Q75N90-mappedCitation-25034023http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25034023
http://purl.uniprot.org/uniprot/#_P35555-mappedCitation-25034023http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25034023
http://purl.uniprot.org/uniprot/#_P35556-mappedCitation-25034023http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25034023
http://purl.uniprot.org/uniprot/P02751http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25034023
http://purl.uniprot.org/uniprot/P35556http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25034023
http://purl.uniprot.org/uniprot/P35555http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25034023
http://purl.uniprot.org/uniprot/Q75N90http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25034023