| http://purl.uniprot.org/citations/25036555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25036555 | http://www.w3.org/2000/01/rdf-schema#comment | "Matrix metalloproteinase-8 (MMP-8)-deficient mice (Mmp8-/-) exhibit delayed dermal wound healing, but also partly contradicting results have been reported. Using the Mmp8-/-mice we investigated the role of MMP-8 in acute wound healing of the mobile tongue, and analyzed the function of tongue fibroblasts in vitro. Interestingly, in the early phase the tongue wounds of Mmp8-/-mice healed faster than those of wild type (wt) mice resulting in significant difference in wound widths (P=0.001, 6-24h). The Mmp8-/-wounds showed no change in myeloperoxidase positive myeloid cell count, but the level of transforming growth factor (TGF)-β1 was significantly increased (P=0.007) compared to the wt tongues. Fibroblasts cultured from wt tongues expressed MMP-8 and TGF-β1. However, higher TGF-β1 levels were detected in Mmp8-/-fibroblasts, and MMP-8 treatment decreased phosphorylated Smad-2 levels and α-smooth muscle actin expression in these fibroblasts suggesting reduced TGF-β1 signaling. Consistently, a degradation of recombinant TGF-β1 by MMP-8 decreased its ability to activate the signaling cascade in fibroblasts. Moreover, collagen gels with Mmp8-/-fibroblasts reduced more in size. We conclude that MMP-8 regulates tongue wound contraction rate and TGF-β1 levels. In vitro analyses suggest that MMP-8 may also play a role in regulating TGF-β1 signaling of stromal fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/25036555 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2014.07.010"xsd:string |
| http://purl.uniprot.org/citations/25036555 | http://purl.uniprot.org/core/author | "Hernandez M."xsd:string |
| http://purl.uniprot.org/citations/25036555 | http://purl.uniprot.org/core/author | "Salo T."xsd:string |
| http://purl.uniprot.org/citations/25036555 | http://purl.uniprot.org/core/author | "Sorsa T."xsd:string |
| http://purl.uniprot.org/citations/25036555 | http://purl.uniprot.org/core/author | "Pirila E."xsd:string |
| http://purl.uniprot.org/citations/25036555 | http://purl.uniprot.org/core/author | "Astrom P."xsd:string |
| http://purl.uniprot.org/citations/25036555 | http://purl.uniprot.org/core/author | "Korpi J.T."xsd:string |
| http://purl.uniprot.org/citations/25036555 | http://purl.uniprot.org/core/author | "Heikkola H."xsd:string |
| http://purl.uniprot.org/citations/25036555 | http://purl.uniprot.org/core/author | "Lithovius R."xsd:string |
| http://purl.uniprot.org/citations/25036555 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25036555 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/25036555 | http://purl.uniprot.org/core/pages | "217-227"xsd:string |
| http://purl.uniprot.org/citations/25036555 | http://purl.uniprot.org/core/title | "Matrix metalloproteinase-8 regulates transforming growth factor-beta1 levels in mouse tongue wounds and fibroblasts in vitro."xsd:string |
| http://purl.uniprot.org/citations/25036555 | http://purl.uniprot.org/core/volume | "328"xsd:string |
| http://purl.uniprot.org/citations/25036555 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25036555 |
| http://purl.uniprot.org/citations/25036555 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25036555 |
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| http://purl.uniprot.org/uniprot/#_Q3TCE6-mappedCitation-25036555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25036555 |
| http://purl.uniprot.org/uniprot/#_Q3TAV4-mappedCitation-25036555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25036555 |
| http://purl.uniprot.org/uniprot/#_Q3TD42-mappedCitation-25036555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25036555 |
| http://purl.uniprot.org/uniprot/#_Q7TPY9-mappedCitation-25036555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25036555 |
| http://purl.uniprot.org/uniprot/#_Q3U1P0-mappedCitation-25036555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25036555 |
| http://purl.uniprot.org/uniprot/#_Q8C209-mappedCitation-25036555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25036555 |