| http://purl.uniprot.org/citations/25037220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25037220 | http://www.w3.org/2000/01/rdf-schema#comment | "Th2 memory lymphocytes have imprinted their Il4 genes epigenetically for expression in dependence of T cell receptor restimulation. However, in a given restimulation, not all Th cells with a memory for IL-4 expression express IL-4. Here, we show that in reactivated Th2 cells, the transcription factors NFATc2, NF-kB p65, c-Maf, p300, Brg1, STAT6, and GATA-3 assemble at the Il4 promoter in Th2 cells expressing IL-4 but not in Th2 cells not expressing it. NFATc2 is critical for assembly of this transcription factor complex. Because NFATc2 translocation into the nucleus occurs in an all-or-none fashion, dependent on complete dephosphorylation by calcineurin, NFATc2 controls the frequencies of cells reexpressing Il4, translates analog differences in T cell receptor stimulation into a digital decision for Il4 reexpression, and instructs all reexpressing cells to express the same amount of IL-4. This analog-to-digital conversion may be critical for the immune system to respond to low concentrations of antigens."xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.587865"xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/author | "Lehmann K."xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/author | "Kock J."xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/author | "Riedel R."xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/author | "Lischke T."xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/author | "Bendfeldt H."xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/author | "Kreher S."xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/author | "Radbruch A."xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/author | "Hatam F."xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/author | "Mashreghi M.F."xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/author | "Chang H.D."xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/author | "Baumgrass R."xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/author | "Haftmann C."xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/author | "Bardua M."xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/author | "Jargosch M."xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/pages | "26752-26761"xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/title | "Nuclear factor of activated T cells regulates the expression of interleukin-4 in Th2 cells in an all-or-none fashion."xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://purl.uniprot.org/core/volume | "289"xsd:string |
| http://purl.uniprot.org/citations/25037220 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25037220 |
| http://purl.uniprot.org/citations/25037220 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25037220 |
| http://purl.uniprot.org/uniprot/#_A2AQC8-mappedCitation-25037220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25037220 |