| http://purl.uniprot.org/citations/25038658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25038658 | http://www.w3.org/2000/01/rdf-schema#comment | "Several bioactive peptides are encrypted within the sequence of major milk proteins, requiring enzymatic proteolysis for release and activation. The present study aimed at the identification of potential anti-inflammatory activities in tryptic hydrolysates of bovine β-casein. Inflammatory processes involve in most cases an activation of Nuclear factor Kappa-light-chain enhancer of activated B cells (NFκB), which is a pro-inflammatory transcription factor of several genes. Hence, a NFκB reporter cell line was established, and TNF-α mediated activation of NFκB was used as a measurement. Bovine β-casein (β-CN) was hydrolysed by trypsin and fractionated by ultrafiltration. Total proteolysate as well as the fraction containing peptides between 1 and 5 kDa showed an inhibitory effect in the cell-based assay, while the fraction containing molecules smaller than 1 kDa did not. This anti-inflammatory effect was ascribed to a group of large, hydrophobic peptides, which were identified using LC-MS. The main peptide was synthesised and showed a significant anti-inflammatory effect in HEK(nfkb-RE)-cells. Thus, for the first time, a casein-derived peptide having an anti-inflammatory effect in vitro has been identified."xsd:string |
| http://purl.uniprot.org/citations/25038658 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.foodchem.2014.05.075"xsd:string |
| http://purl.uniprot.org/citations/25038658 | http://purl.uniprot.org/core/author | "Meisel H."xsd:string |
| http://purl.uniprot.org/citations/25038658 | http://purl.uniprot.org/core/author | "Klempt M."xsd:string |
| http://purl.uniprot.org/citations/25038658 | http://purl.uniprot.org/core/author | "Malinowski J."xsd:string |
| http://purl.uniprot.org/citations/25038658 | http://purl.uniprot.org/core/author | "Clawin-Radecker I."xsd:string |
| http://purl.uniprot.org/citations/25038658 | http://purl.uniprot.org/core/author | "Lorenzen P.C."xsd:string |
| http://purl.uniprot.org/citations/25038658 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25038658 | http://purl.uniprot.org/core/name | "Food Chem"xsd:string |
| http://purl.uniprot.org/citations/25038658 | http://purl.uniprot.org/core/pages | "129-133"xsd:string |
| http://purl.uniprot.org/citations/25038658 | http://purl.uniprot.org/core/title | "Identification of a NFkappaB inhibitory peptide from tryptic beta-casein hydrolysate."xsd:string |
| http://purl.uniprot.org/citations/25038658 | http://purl.uniprot.org/core/volume | "165"xsd:string |
| http://purl.uniprot.org/citations/25038658 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25038658 |
| http://purl.uniprot.org/citations/25038658 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25038658 |
| http://purl.uniprot.org/uniprot/P02666#attribution-B9C97439C850B17EFCF7C91F91BDC999 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25038658 |
| http://purl.uniprot.org/uniprot/P25963#attribution-B9C97439C850B17EFCF7C91F91BDC999 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25038658 |
| http://purl.uniprot.org/uniprot/P25963#attribution-E7CBD3AACB7390D9016CF06A8039F467 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25038658 |
| http://purl.uniprot.org/uniprot/P00761#attribution-B9C97439C850B17EFCF7C91F91BDC999 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25038658 |