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http://purl.uniprot.org/citations/25041756http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25041756http://www.w3.org/2000/01/rdf-schema#comment"

Aim

Hypertension is a major clinical complication of obesity. Our previous studies show that abnormal uptake of the nitric oxide precursor L-arginine, via the cationic amino acid transporter-1 (CAT1), contributes to endothelial dysfunction in cardiovascular disease. In this study, we tested the hypothesis that abnormal L-arginine transport may be a key mediator of obesity-induced hypertension.

Methods

Mean arterial pressure (MAP) was monitored by telemetry in conscious wild-type (WT; n = 13) mice, and transgenic mice with endothelial-specific overexpression of CAT1 (CAT+; n = 14) fed a normal or a high fat diet for 20 weeks. Renal angiotensin II (Ang II), CAT1 mRNA and plasma nitrate/nitrite levels were then quantified. In conjunction, plasma nitrate/nitrite levels were assessed in obese normotensive (n = 15) and obese hypertensive subjects (n = 15).

Results

Both genotypes of mice developed obesity when fed a high fat diet (P ≤ 0.002). Fat fed WT mice had 13% greater MAP and 78% greater renal Ang II content, 42% lesser renal CAT1 mRNA levels and 42% lesser plasma nitrate/nitrite levels, than WT mice fed a normal fat diet (P ≤ 0.02). In contrast, none of these variables were significantly altered by high fat feeding in CAT+ mice (P ≥ 0.36). Plasma nitrate/nitrite levels were 17% less in obese hypertensives compared with obese normotensives (P = 0.02).

Conclusion

Collectively, these data indicate that obesity-induced down-regulation of CAT1 expression and subsequent reduced bioavailability of nitric oxide may contribute to the development of obesity-induced hypertension."xsd:string
http://purl.uniprot.org/citations/25041756http://purl.org/dc/terms/identifier"doi:10.1111/apha.12344"xsd:string
http://purl.uniprot.org/citations/25041756http://purl.uniprot.org/core/author"Fernandez S."xsd:string
http://purl.uniprot.org/citations/25041756http://purl.uniprot.org/core/author"Kaye D.M."xsd:string
http://purl.uniprot.org/citations/25041756http://purl.uniprot.org/core/author"Rajapakse N.W."xsd:string
http://purl.uniprot.org/citations/25041756http://purl.uniprot.org/core/author"Karim F."xsd:string
http://purl.uniprot.org/citations/25041756http://purl.uniprot.org/core/author"Head G.A."xsd:string
http://purl.uniprot.org/citations/25041756http://purl.uniprot.org/core/author"Evans R.G."xsd:string
http://purl.uniprot.org/citations/25041756http://purl.uniprot.org/core/author"Straznicky N.E."xsd:string
http://purl.uniprot.org/citations/25041756http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/25041756http://purl.uniprot.org/core/name"Acta Physiol (Oxf)"xsd:string
http://purl.uniprot.org/citations/25041756http://purl.uniprot.org/core/pages"39-48"xsd:string
http://purl.uniprot.org/citations/25041756http://purl.uniprot.org/core/title"Augmented endothelial-specific L-arginine transport prevents obesity-induced hypertension."xsd:string
http://purl.uniprot.org/citations/25041756http://purl.uniprot.org/core/volume"212"xsd:string
http://purl.uniprot.org/citations/25041756http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25041756
http://purl.uniprot.org/citations/25041756http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25041756
http://purl.uniprot.org/uniprot/#_A2JY27-mappedCitation-25041756http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25041756
http://purl.uniprot.org/uniprot/#_Q91WD2-mappedCitation-25041756http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25041756
http://purl.uniprot.org/uniprot/#_Q9JJJ0-mappedCitation-25041756http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25041756
http://purl.uniprot.org/uniprot/Q91WD2http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25041756
http://purl.uniprot.org/uniprot/Q9JJJ0http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25041756
http://purl.uniprot.org/uniprot/A2JY27http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25041756