| http://purl.uniprot.org/citations/25043021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25043021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25043021 | http://www.w3.org/2000/01/rdf-schema#comment | "During cap-dependent eukaryotic translation initiation, ribosomes scan messenger RNA from the 5' end to the first AUG start codon with favourable sequence context. For many mRNAs this AUG belongs to a short upstream open reading frame (uORF), and translation of the main downstream ORF requires re-initiation, an incompletely understood process. Re-initiation is thought to involve the same factors as standard initiation. It is unknown whether any factors specifically affect translation re-initiation without affecting standard cap-dependent translation. Here we uncover the non-canonical initiation factors density regulated protein (DENR) and multiple copies in T-cell lymphoma-1 (MCT-1; also called MCTS1 in humans) as the first selective regulators of eukaryotic re-initiation. mRNAs containing upstream ORFs with strong Kozak sequences selectively require DENR-MCT-1 for their proper translation, yielding a novel class of mRNAs that can be co-regulated and that is enriched for regulatory proteins such as oncogenic kinases. Collectively, our data reveal that cells have a previously unappreciated translational control system with a key role in supporting proliferation and tissue growth."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature13401"xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature13401"xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Schleich S."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Schleich S."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Stoecklin G."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Stoecklin G."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Teleman A.A."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Teleman A.A."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Kuchler K."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Kuchler K."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Cheng Y.S."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Cheng Y.S."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Duncan K.E."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Duncan K.E."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Janiesch P.C."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Janiesch P.C."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Miller K.K."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Miller K.K."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Haneke K."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Haneke K."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Koledachkina T."xsd:string |
| http://purl.uniprot.org/citations/25043021 | http://purl.uniprot.org/core/author | "Koledachkina T."xsd:string |