| http://purl.uniprot.org/citations/25049354 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25049354 | http://www.w3.org/2000/01/rdf-schema#comment | "Matrix metalloproteinases (MMPs) play important roles in normal brain development and synaptic plasticity, although aberrant expression of MMPs leads to brain damage, including blood-brain barrier disruption, inflammation, demyelination, and neuronal cell death. In this article, we report that MMP-8 is upregulated in LPS-stimulated BV2 microglial cells and primary cultured microglia, and treatment of MMP-8 inhibitor (M8I) or MMP-8 short hairpin RNA suppresses proinflammatory molecules, particularly TNF-α secretion. Subsequent experiments showed that MMP-8 exhibits TNF-α-converting enzyme (TACE) activity by cleaving the prodomain of TNF-α (A(74)/Q(75), A(76)/V(77) residues) and, furthermore, that M8I inhibits TACE activity more efficiently than TAPI-0, a general TACE inhibitor. Biochemical analysis of the underlying anti-inflammatory mechanisms of M8I revealed that it inhibits MAPK phosphorylation, NF-κB/AP-1 activity, and reactive oxygen species production. Further support for the proinflammatory role of microglial MMP-8 was obtained from an in vivo animal model of neuroinflammatory disorder. MMP-8 is upregulated in septic conditions, particularly in microglia. Administration of M8I or MMP-8 short hairpin RNA significantly inhibits microglial activation and expression/secretion of TNF-α in brain tissue, serum, and cerebrospinal fluid of LPS-induced septic mice. These results demonstrate that MMP-8 critically mediates microglial activation by modulating TNF-α activity, which may explain neuroinflammation in septic mouse brain."xsd:string |
| http://purl.uniprot.org/citations/25049354 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1303240"xsd:string |
| http://purl.uniprot.org/citations/25049354 | http://purl.uniprot.org/core/author | "Kim H.S."xsd:string |
| http://purl.uniprot.org/citations/25049354 | http://purl.uniprot.org/core/author | "Lee E.J."xsd:string |
| http://purl.uniprot.org/citations/25049354 | http://purl.uniprot.org/core/author | "Choi J.W."xsd:string |
| http://purl.uniprot.org/citations/25049354 | http://purl.uniprot.org/core/author | "Son W.S."xsd:string |
| http://purl.uniprot.org/citations/25049354 | http://purl.uniprot.org/core/author | "Park E.M."xsd:string |
| http://purl.uniprot.org/citations/25049354 | http://purl.uniprot.org/core/author | "Baek M.C."xsd:string |
| http://purl.uniprot.org/citations/25049354 | http://purl.uniprot.org/core/author | "Shin J.A."xsd:string |
| http://purl.uniprot.org/citations/25049354 | http://purl.uniprot.org/core/author | "Han J.E."xsd:string |
| http://purl.uniprot.org/citations/25049354 | http://purl.uniprot.org/core/author | "Woo M.S."xsd:string |
| http://purl.uniprot.org/citations/25049354 | http://purl.uniprot.org/core/author | "Ko Y.T."xsd:string |
| http://purl.uniprot.org/citations/25049354 | http://purl.uniprot.org/core/author | "Kang J.L."xsd:string |
| http://purl.uniprot.org/citations/25049354 | http://purl.uniprot.org/core/author | "Moon P.G."xsd:string |
| http://purl.uniprot.org/citations/25049354 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25049354 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/25049354 | http://purl.uniprot.org/core/pages | "2384-2393"xsd:string |
| http://purl.uniprot.org/citations/25049354 | http://purl.uniprot.org/core/title | "Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-alpha activation."xsd:string |
| http://purl.uniprot.org/citations/25049354 | http://purl.uniprot.org/core/volume | "193"xsd:string |
| http://purl.uniprot.org/citations/25049354 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25049354 |
| http://purl.uniprot.org/citations/25049354 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25049354 |
| http://purl.uniprot.org/uniprot/P78536#attribution-B4E0D4A3144166493ED31D0FE70EABC0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25049354 |
| http://purl.uniprot.org/uniprot/P14780#attribution-FD386504EEC8E35C173FE6855A4F7ABE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25049354 |
| http://purl.uniprot.org/uniprot/O88766#attribution-C5E39A4472083730FA22EC7A7D74AC24 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25049354 |