| http://purl.uniprot.org/citations/25049408 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25049408 | http://www.w3.org/2000/01/rdf-schema#comment | "Semaphorin family proteins are well-known axon guidance ligands. Recent studies indicate that certain transmembrane Semaphorins can also function as guidance receptors to mediate axon-axon attraction or repulsion. The mechanisms by which Semaphorin reverse signaling modulates axon-surface affinity, however, remain unknown. In this study, we reveal a novel mechanism underlying upregulation of axon-axon attraction by Semaphorin-1a (Sema1a) reverse signaling in the developing Drosophila visual system. Sema1a promotes the phosphorylation and activation of Moesin (Moe), a member of the ezrin/radixin/moesin family of proteins, and downregulates the level of active Rho1 in photoreceptor axons. We propose that Sema1a reverse signaling activates Moe, which in turn upregulates Fas2-mediated axon-axon attraction by inhibiting Rho1."xsd:string |
| http://purl.uniprot.org/citations/25049408 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1321433111"xsd:string |
| http://purl.uniprot.org/citations/25049408 | http://purl.uniprot.org/core/author | "Chang W.T."xsd:string |
| http://purl.uniprot.org/citations/25049408 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/25049408 | http://purl.uniprot.org/core/author | "Rao Y."xsd:string |
| http://purl.uniprot.org/citations/25049408 | http://purl.uniprot.org/core/author | "Hsieh H.H."xsd:string |
| http://purl.uniprot.org/citations/25049408 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25049408 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/25049408 | http://purl.uniprot.org/core/pages | "11383-11388"xsd:string |
| http://purl.uniprot.org/citations/25049408 | http://purl.uniprot.org/core/title | "Control of axon-axon attraction by Semaphorin reverse signaling."xsd:string |
| http://purl.uniprot.org/citations/25049408 | http://purl.uniprot.org/core/volume | "111"xsd:string |
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