| http://purl.uniprot.org/citations/25053409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25053409 | http://www.w3.org/2000/01/rdf-schema#comment | "Rapamycin at high doses (2-10 mg/kg body weight) inhibits mammalian target of rapamycin complex 1 (mTORC1) and protein synthesis in mice. In contrast, low doses of rapamycin (10 μg/kg) increase mTORC1 activity and protein synthesis in skeletal muscle. Similar changes are found with SLF (synthetic ligand for FKBP12, which does not inhibit mTORC1) and in mice with a skeletal muscle-specific FKBP12 deficiency. These interventions also increase Ca(2+) influx to enhance refilling of sarcoplasmic reticulum Ca(2+) stores, slow muscle fatigue, and increase running endurance without negatively impacting cardiac function. FKBP12 deficiency or longer treatments with low dose rapamycin or SLF increase the percentage of type I fibers, further adding to fatigue resistance. We demonstrate that FKBP12 and its ligands impact multiple aspects of muscle function."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.586289"xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Long C."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Lee C.S."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Tran T."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Ji R."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Knoblauch M."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Georgiou D.K."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Hamilton S.L."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Monroe T.O."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Ismailov I.I."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Bayle J.H."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Joshi A.D."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Lanner J.T."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Ingalls C.P."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Durham W.J."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Narkar V.A."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Oakes J."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Corona B.T."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Hanna A.D."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Lorca S."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/author | "Dagnino-Acosta A."xsd:string |
| http://purl.uniprot.org/citations/25053409 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |