| http://purl.uniprot.org/citations/25053429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25053429 | http://www.w3.org/2000/01/rdf-schema#comment | "A complex regulatory network of morphogens and transcription factors is essential for normal cardiac development. Nkx2-5 is among the earliest known markers of cardiac mesoderm that is central to the regulatory pathways mediating second heart field (SHF) development. Here, we have examined the specific requirements for Nkx2-5 in the SHF progenitors. We show that Nkx2-5 potentiates Wnt signaling by regulating the expression of the R-spondin3 (Rspo3) gene during cardiogenesis. R-spondins are secreted factors and potent Wnt agonists that in part regulate stem cell proliferation. Our data show that Rspo3 is markedly downregulated in Nkx2-5 mutants and that Rspo3 expression is regulated by Nkx2-5. Conditional inactivation of Rspo3 in the Isl1 lineage resulted in embryonic lethality secondary to impaired development of SHF. More importantly, we find that Wnt signaling is significantly attenuated in Nkx2-5 mutants and that enhancing Wnt/β-catenin signaling by pharmacological treatment or by transgenic expression of Rspo3 rescues the SHF defects in the conditional Nkx2-5(+/-) mutants. We have identified a previously unrecognized genetic link between Nkx2-5 and Wnt signaling that supports continued cardiac growth and proliferation during development. Identification of Rspo3 in cardiac development provides a new paradigm in temporal regulation of Wnt signaling by cardiac-specific transcription factors."xsd:string |
| http://purl.uniprot.org/citations/25053429 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.103416"xsd:string |
| http://purl.uniprot.org/citations/25053429 | http://purl.uniprot.org/core/author | "Pashmforoush M."xsd:string |
| http://purl.uniprot.org/citations/25053429 | http://purl.uniprot.org/core/author | "Cambier L."xsd:string |
| http://purl.uniprot.org/citations/25053429 | http://purl.uniprot.org/core/author | "Plate M."xsd:string |
| http://purl.uniprot.org/citations/25053429 | http://purl.uniprot.org/core/author | "Sucov H.M."xsd:string |
| http://purl.uniprot.org/citations/25053429 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25053429 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/25053429 | http://purl.uniprot.org/core/pages | "2959-2971"xsd:string |
| http://purl.uniprot.org/citations/25053429 | http://purl.uniprot.org/core/title | "Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3."xsd:string |
| http://purl.uniprot.org/citations/25053429 | http://purl.uniprot.org/core/volume | "141"xsd:string |
| http://purl.uniprot.org/citations/25053429 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25053429 |
| http://purl.uniprot.org/citations/25053429 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25053429 |
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| http://purl.uniprot.org/uniprot/#_A0A0A6YXU9-mappedCitation-25053429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25053429 |
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| http://purl.uniprot.org/uniprot/#_A0A0A0MQF6-mappedCitation-25053429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25053429 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUD9-mappedCitation-25053429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25053429 |
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| http://purl.uniprot.org/uniprot/#_D3Z0I3-mappedCitation-25053429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25053429 |