| http://purl.uniprot.org/citations/25057013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25057013 | http://www.w3.org/2000/01/rdf-schema#comment | "The plasma membrane delineates the cell and mediates its communication and material exchange with the environment. Many processes of the plasma membrane occur through interactions of proteins with phosphatidylinositol(4,5)-bisphosphate (PI(4,5)P2), which is highly enriched in this membrane and is a key determinant of its identity. Eisosomes function in lateral organization of the plasma membrane, but the molecular function of their major protein subunits, the BAR domain-containing proteins Pil1 and Lsp1, is poorly understood. Here we show that eisosomes interact with the PI(4,5)P2 phosphatase Inp51/Sjl1, thereby recruiting it to the plasma membrane. Pil1 is essential for plasma membrane localization and function of Inp51 but not for the homologous phosphatidylinositol bisphosphate phosphatases Inp52/Sjl2 and Inp53/Sjl3. Consistent with this, absence of Pil1 increases total and available PI(4,5)P2 levels at the plasma membrane. On the basis of these findings, we propose a model in which the eisosomes function in maintaining PI(4,5)P2 levels by Inp51/Sjl1 recruitment."xsd:string |
| http://purl.uniprot.org/citations/25057013 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e13-11-0639"xsd:string |
| http://purl.uniprot.org/citations/25057013 | http://purl.uniprot.org/core/author | "Walther T.C."xsd:string |
| http://purl.uniprot.org/citations/25057013 | http://purl.uniprot.org/core/author | "Christiano R."xsd:string |
| http://purl.uniprot.org/citations/25057013 | http://purl.uniprot.org/core/author | "Frohlich F."xsd:string |
| http://purl.uniprot.org/citations/25057013 | http://purl.uniprot.org/core/author | "Olson D.K."xsd:string |
| http://purl.uniprot.org/citations/25057013 | http://purl.uniprot.org/core/author | "Alcazar-Roman A."xsd:string |
| http://purl.uniprot.org/citations/25057013 | http://purl.uniprot.org/core/author | "DeCamilli P."xsd:string |
| http://purl.uniprot.org/citations/25057013 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25057013 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/25057013 | http://purl.uniprot.org/core/pages | "2797-2806"xsd:string |
| http://purl.uniprot.org/citations/25057013 | http://purl.uniprot.org/core/title | "A role for eisosomes in maintenance of plasma membrane phosphoinositide levels."xsd:string |
| http://purl.uniprot.org/citations/25057013 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/25057013 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25057013 |
| http://purl.uniprot.org/citations/25057013 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25057013 |
| http://purl.uniprot.org/uniprot/#_P34250-mappedCitation-25057013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25057013 |
| http://purl.uniprot.org/uniprot/#_Q03407-mappedCitation-25057013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25057013 |
| http://purl.uniprot.org/uniprot/#_P15891-mappedCitation-25057013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25057013 |
| http://purl.uniprot.org/uniprot/#_Q12230-mappedCitation-25057013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25057013 |
| http://purl.uniprot.org/uniprot/#_Q12271-mappedCitation-25057013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25057013 |
| http://purl.uniprot.org/uniprot/#_P50942-mappedCitation-25057013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25057013 |
| http://purl.uniprot.org/uniprot/#_P40559-mappedCitation-25057013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25057013 |
| http://purl.uniprot.org/uniprot/#_Q04279-mappedCitation-25057013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25057013 |
| http://purl.uniprot.org/uniprot/#_Q05812-mappedCitation-25057013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25057013 |