| http://purl.uniprot.org/citations/25058508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25058508 | http://www.w3.org/2000/01/rdf-schema#comment | "The oncoprotein Tax of human T-cell leukemia virus type 1 (HTLV-1) is a potent transactivator of viral and cellular transcription. Here, we identified ELL2 as the sole transcription elongation factor to be specifically upregulated in HTLV-1-/Tax-transformed T-cells. Tax contributes to regulation of ELL2, since transient transfection of Tax increases ELL2 mRNA, Tax transactivates the ELL2 promoter, and repression of Tax results in decrease of ELL2 in transformed T-lymphocytes. However, we also measured upregulation of ELL2 in HTLV-1-transformed cells exhibiting undetectable amounts of Tax, suggesting that ELL2 can still be maintained independent of continuous Tax expression. We further show that Tax and ELL2 synergistically activate the HTLV-1 promoter, indicating that ELL2 cooperates with Tax in viral transactivation. This is supported by our findings that Tax and ELL2 accumulate in nuclear fractions and that they co-precipitate upon co-expression in transiently-transfected cells. Thus, upregulation of ELL2 could contribute to HTLV-1 gene regulation."xsd:string |
| http://purl.uniprot.org/citations/25058508 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2014.06.028"xsd:string |
| http://purl.uniprot.org/citations/25058508 | http://purl.uniprot.org/core/author | "Fleckenstein B."xsd:string |
| http://purl.uniprot.org/citations/25058508 | http://purl.uniprot.org/core/author | "Kress A.K."xsd:string |
| http://purl.uniprot.org/citations/25058508 | http://purl.uniprot.org/core/author | "Strobel S."xsd:string |
| http://purl.uniprot.org/citations/25058508 | http://purl.uniprot.org/core/author | "Mann M.C."xsd:string |
| http://purl.uniprot.org/citations/25058508 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25058508 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/25058508 | http://purl.uniprot.org/core/pages | "98-110"xsd:string |
| http://purl.uniprot.org/citations/25058508 | http://purl.uniprot.org/core/title | "The transcription elongation factor ELL2 is specifically upregulated in HTLV-1-infected T-cells and is dependent on the viral oncoprotein Tax."xsd:string |
| http://purl.uniprot.org/citations/25058508 | http://purl.uniprot.org/core/volume | "464-465"xsd:string |
| http://purl.uniprot.org/citations/25058508 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25058508 |
| http://purl.uniprot.org/citations/25058508 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25058508 |
| http://purl.uniprot.org/uniprot/#_B4DTQ1-mappedCitation-25058508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25058508 |
| http://purl.uniprot.org/uniprot/#_B4DL71-mappedCitation-25058508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25058508 |
| http://purl.uniprot.org/uniprot/#_O00472-mappedCitation-25058508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25058508 |
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| http://purl.uniprot.org/uniprot/#_Q7Z656-mappedCitation-25058508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25058508 |
| http://purl.uniprot.org/uniprot/B4DL71 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25058508 |
| http://purl.uniprot.org/uniprot/Q59FW6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25058508 |
| http://purl.uniprot.org/uniprot/O00472 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25058508 |
| http://purl.uniprot.org/uniprot/Q7Z656 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25058508 |
| http://purl.uniprot.org/uniprot/B4DTQ1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25058508 |