| http://purl.uniprot.org/citations/25061667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25061667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25061667 | http://www.w3.org/2000/01/rdf-schema#comment | "Processing bodies (PBs) and stress granules (SGs) are related, cytoplasmic RNA-protein complexes that contribute to post-transcriptional gene regulation in all eukaryotic cells. Both structures contain translationally repressed mRNAs and several proteins involved in silencing, stabilization or degradation of mRNAs, especially under environmental stress. Here, we monitored the dynamic formation of PBs and SGs, in somatic cells of adult worms, using fluorescently tagged protein markers of each complex. Both complexes were accumulated in response to various stress conditions, but distinct modes of SG formation were induced, depending on the insult. We also observed an age-dependent accumulation of PBs but not of SGs. We further showed that direct alterations in PB-related genes can influence aging and normal stress responses, beyond their developmental role. In addition, disruption of SG-related genes had diverse effects on development, fertility, lifespan and stress resistance of worms. Our work therefore underlines the important roles of mRNA metabolism factors in several vital cellular processes and provides insight into their diverse functions in a multicellular organism."xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0103365"xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0103365"xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/author | "Syntichaki P."xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/author | "Syntichaki P."xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/author | "Vlanti A."xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/author | "Vlanti A."xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/author | "Borbolis F."xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/author | "Borbolis F."xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/author | "Kapetanou M."xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/author | "Kapetanou M."xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/author | "Roumelioti F."xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/author | "Roumelioti F."xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/author | "Rousakis A."xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/author | "Rousakis A."xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/pages | "e103365"xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/pages | "e103365"xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/title | "Diverse functions of mRNA metabolism factors in stress defense and aging of Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/25061667 | http://purl.uniprot.org/core/title | "Diverse functions of mRNA metabolism factors in stress defense and aging of Caenorhabditis elegans."xsd:string |