| http://purl.uniprot.org/citations/25062971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25062971 | http://www.w3.org/2000/01/rdf-schema#comment | "Roquin-1, a RING finger E3 ubiquitin ligase, functions as a modulator of inflammation; however, nothing is known about how Rc3h1 expression is regulated. Here, we describe an opposing relationship between Roquin-1 and the IL-17 proinflammatory cytokine by demonstrating that enforced expression of Rc3h1 restricts Il17a expression, and that exposure of T cells to IL-10, a cytokine with immunosuppressive activity, increases Rc3h1 expression. Luciferase reporter assays conducted using eight transcription factor plasmids (STAT1, STAT3, STAT5, GATA2, c-Rel, IKZF1, IKZF2, and IKZF3) demonstrated that STAT1, STAT3, GATA2, and c-Rel increased Rc3h1 promoter activity, whereas IKZF2 decreased activity. Gene expression of those five transcription factors increased in T cells exposed to IL-10. Transcription factor-specific siRNAs suppressed the IL-10 effect on Rc3h1 transcription. These findings identify a role for IL-10 in regulating Rc3h1 transcription, and they have implications for understanding how Roquin-1 controls the immune response."xsd:string |
| http://purl.uniprot.org/citations/25062971 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2014.07.056"xsd:string |
| http://purl.uniprot.org/citations/25062971 | http://purl.uniprot.org/core/author | "Klein J.R."xsd:string |
| http://purl.uniprot.org/citations/25062971 | http://purl.uniprot.org/core/author | "Montufar-Solis D."xsd:string |
| http://purl.uniprot.org/citations/25062971 | http://purl.uniprot.org/core/author | "Schaefer J.S."xsd:string |
| http://purl.uniprot.org/citations/25062971 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25062971 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/25062971 | http://purl.uniprot.org/core/pages | "134-140"xsd:string |
| http://purl.uniprot.org/citations/25062971 | http://purl.uniprot.org/core/title | "A role for IL-10 in the transcriptional regulation of Roquin-1."xsd:string |
| http://purl.uniprot.org/citations/25062971 | http://purl.uniprot.org/core/volume | "549"xsd:string |
| http://purl.uniprot.org/citations/25062971 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25062971 |
| http://purl.uniprot.org/citations/25062971 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25062971 |
| http://purl.uniprot.org/uniprot/#_A0A668KLW6-mappedCitation-25062971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25062971 |
| http://purl.uniprot.org/uniprot/#_B3VI66-mappedCitation-25062971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25062971 |
| http://purl.uniprot.org/uniprot/#_Q62386-mappedCitation-25062971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25062971 |
| http://purl.uniprot.org/uniprot/#_Q71UZ1-mappedCitation-25062971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25062971 |
| http://purl.uniprot.org/uniprot/#_H7BX02-mappedCitation-25062971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25062971 |
| http://purl.uniprot.org/uniprot/#_Q3UT88-mappedCitation-25062971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25062971 |
| http://purl.uniprot.org/uniprot/#_Q4VGL6-mappedCitation-25062971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25062971 |
| http://purl.uniprot.org/uniprot/#_Q6FGW4-mappedCitation-25062971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25062971 |
| http://purl.uniprot.org/uniprot/#_P22301-mappedCitation-25062971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25062971 |
| http://purl.uniprot.org/uniprot/#_Q3TS82-mappedCitation-25062971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25062971 |
| http://purl.uniprot.org/uniprot/#_Q544E6-mappedCitation-25062971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25062971 |
| http://purl.uniprot.org/uniprot/#_Q9BXR7-mappedCitation-25062971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25062971 |