| http://purl.uniprot.org/citations/25063677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25063677 | http://www.w3.org/2000/01/rdf-schema#comment | "Compartmentalization of Toll-like receptors (TLRs) in intestinal epithelial cells (IECs) regulates distinct immune responses to microbes; however, the specific cellular machinery that controls this mechanism has not been fully identified. Here we provide genetic evidences that the recycling endosomal compartment in enterocytes maintains a homeostatic TLR9 intracellular distribution, supporting mucosal tolerance to normal microbiota. Genetic ablation of a recycling endosome resident small GTPase, Rab11a, a gene adjacent to a Crohn's disease risk locus, in mouse IECs and in Drosophila midgut caused epithelial cell-intrinsic cytokine production, inflammatory bowel phenotype, and early mortality. Unlike wild-type controls, germ-free Rab11a-deficient mouse intestines failed to tolerate the intraluminal stimulation of microbial agonists. Thus, Rab11a endosome controls intestinal host-microbial homeostasis at least partially via sorting TLRs."xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.201487888"xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://purl.uniprot.org/core/author | "Nie Y."xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://purl.uniprot.org/core/author | "Yu S."xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://purl.uniprot.org/core/author | "Das S."xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://purl.uniprot.org/core/author | "Patel C."xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://purl.uniprot.org/core/author | "Ip Y.T."xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://purl.uniprot.org/core/author | "Gao N."xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://purl.uniprot.org/core/author | "Goldenring J.R."xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://purl.uniprot.org/core/author | "Stypulkowski E."xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://purl.uniprot.org/core/author | "Ferraris R.P."xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://purl.uniprot.org/core/author | "Douard V."xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://purl.uniprot.org/core/author | "Bonder E.M."xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://purl.uniprot.org/core/author | "Knowles B."xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://purl.uniprot.org/core/author | "Sakamori R."xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25063677 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://purl.uniprot.org/core/pages | "1882-1895"xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://purl.uniprot.org/core/title | "TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis."xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/25063677 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25063677 |
| http://purl.uniprot.org/citations/25063677 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25063677 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF4-mappedCitation-25063677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25063677 |
| http://purl.uniprot.org/uniprot/#_D3Z7Q6-mappedCitation-25063677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25063677 |