| http://purl.uniprot.org/citations/25063872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25063872 | http://www.w3.org/2000/01/rdf-schema#comment | "To determine whether IFN-α is a cause of the T cell hyperactivation and IL-7 signaling pathway defects that are observed in some HIV patients receiving antiretroviral therapy, we have investigated the effect of IFN-α on the proliferation of CD4(+) and CD8(+) T cells from healthy donors (n = 30) and treated HIV(+) donors (n = 20). PBMC were cultured for 7 d with staphylococcal enterotoxin B or IL-7 in the absence or presence of 100 U/ml IFN-α8. Total and naive CD4(+) and CD8(+) T cells were assessed for proliferation (via Ki67 expression), CD127 expression, and phosphorylated STAT5 levels using flow cytometry. IFN-α significantly enhanced activation-induced proliferation (via staphylococcal enterotoxin B stimulation) but inhibited homeostatic proliferation (IL-7 induced) of CD4(+) and CD8(+) T cells. Both of these effects may adversely affect CD4(+) T cell homeostasis in HIV patients. CD127 expression was increased in both healthy and HIV(+) donors following culture with IFN-α8, and levels of IL-7-induced phosphorylated STAT5 were increased by IFN-α8 in healthy donors only. Hence, the inhibitory effects of IFN-α on IL-7-induced proliferation of CD4(+) T cells are unlikely to be mediated by downregulation of CD127 expression or inhibition of STAT5 phosphorylation. These data suggest that increased IFN-α activity may promote the loss of T cells by accelerating cell turnover and activation-induced cell death while decreasing the renewal of T cells by inhibiting the proliferative effect of IL-7."xsd:string |
| http://purl.uniprot.org/citations/25063872 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1302536"xsd:string |
| http://purl.uniprot.org/citations/25063872 | http://purl.uniprot.org/core/author | "Cha L."xsd:string |
| http://purl.uniprot.org/citations/25063872 | http://purl.uniprot.org/core/author | "Fernandez S."xsd:string |
| http://purl.uniprot.org/citations/25063872 | http://purl.uniprot.org/core/author | "de Jong E."xsd:string |
| http://purl.uniprot.org/citations/25063872 | http://purl.uniprot.org/core/author | "French M.A."xsd:string |
| http://purl.uniprot.org/citations/25063872 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25063872 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/25063872 | http://purl.uniprot.org/core/pages | "2178-2186"xsd:string |
| http://purl.uniprot.org/citations/25063872 | http://purl.uniprot.org/core/title | "IFN-alpha exerts opposing effects on activation-induced and IL-7-induced proliferation of T cells that may impair homeostatic maintenance of CD4+ T cell numbers in treated HIV infection."xsd:string |
| http://purl.uniprot.org/citations/25063872 | http://purl.uniprot.org/core/volume | "193"xsd:string |
| http://purl.uniprot.org/citations/25063872 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25063872 |
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