| http://purl.uniprot.org/citations/25065622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25065622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25065622 | http://www.w3.org/2000/01/rdf-schema#comment | "The β-galactoside-binding protein galectin-9 is critical in regulating the immune response, but the mechanism by which it functions remains unclear. We have demonstrated that galectin-9 is highly expressed by induced regulatory T cells (iTreg) and was crucial for the generation and function of iTreg cells, but not natural regulatory T (nTreg) cells. Galectin-9 expression within iTreg cells was driven by the transcription factor Smad3, forming a feed-forward loop, which further promoted Foxp3 expression. Galectin-9 increased iTreg cell stability and function by directly binding to its receptor CD44, which formed a complex with transforming growth factor-β (TGF-β) receptor I (TGF-βRI), and activated Smad3. Galectin-9 signaling was further found to regulate iTreg cell induction by dominantly acting through the CNS1 region of the Foxp3 locus. Our data suggest that exogenous galectin-9, in addition to being an effector molecule for Treg cells, acts synergistically with TGF-β to enforce iTreg cell differentiation and maintenance."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2014.06.011"xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2014.06.011"xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Xiao S."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Xiao S."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Anderson A.C."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Anderson A.C."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Zhu C."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Zhu C."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Hirashima M."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Hirashima M."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Franca R.F."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Franca R.F."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Hotta C."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Hotta C."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Kuchroo V.K."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Kuchroo V.K."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Thalhamer T."xsd:string |
| http://purl.uniprot.org/citations/25065622 | http://purl.uniprot.org/core/author | "Thalhamer T."xsd:string |