| http://purl.uniprot.org/citations/25071083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25071083 | http://www.w3.org/2000/01/rdf-schema#comment | "Rhophilin-1 is a Rho GTPase-interacting protein, the biologic function of which is largely unknown. Here, we identify and describe the functional role of Rhophilin-1 as a novel podocyte-specific protein of the kidney glomerulus. Rhophilin-1 knockout mice were phenotypically normal at birth but developed albuminuria at about 2 weeks of age. Kidneys from severely albuminuric mice revealed widespread podocyte foot process effacement, thickening of the glomerular basement membrane, and FSGS-like lesions. The absence of any overt changes in the expression of podocyte proteins at the onset of proteinuria suggested that the primary cause of podocyte abnormalities in Rhpn1-null mice was the result of cell-autonomous, Rhophilin-1-dependent signaling events. In culture, Rhophilin-1 was detected at the plasma membrane leading edge of primary podocytes, where it elicited remodeling of the actin cytoskeleton network. This effect of Rhophilin-1 on actin cytoskeleton organization associated with inhibitory effects on Rho-dependent phosphorylation of the myosin regulatory light chain and stress fiber formation. Conversely, phosphorylation of myosin regulatory light chain increased in podocyte foot processes of Rhpn1(-/-) mice, implicating altered actinomyosin contractility in foot process effacement and compromised filtration capacity. Targeted deletion of RhoA in podocytes of Rhophilin-1 knockout mice exacerbated the renal injury. Taken together, our results indicate that Rhophilin-1 is essential for the integrity of the glomerular filtration barrier and that this protein is a key determinant of podocyte cytoskeleton architecture."xsd:string |
| http://purl.uniprot.org/citations/25071083 | http://purl.org/dc/terms/identifier | "doi:10.1681/asn.2013111195"xsd:string |
| http://purl.uniprot.org/citations/25071083 | http://purl.uniprot.org/core/author | "Katayama K."xsd:string |
| http://purl.uniprot.org/citations/25071083 | http://purl.uniprot.org/core/author | "Xiao Z."xsd:string |
| http://purl.uniprot.org/citations/25071083 | http://purl.uniprot.org/core/author | "Hultenby K."xsd:string |
| http://purl.uniprot.org/citations/25071083 | http://purl.uniprot.org/core/author | "Tryggvason K."xsd:string |
| http://purl.uniprot.org/citations/25071083 | http://purl.uniprot.org/core/author | "Nukui M."xsd:string |
| http://purl.uniprot.org/citations/25071083 | http://purl.uniprot.org/core/author | "Wernerson A."xsd:string |
| http://purl.uniprot.org/citations/25071083 | http://purl.uniprot.org/core/author | "Andersson A.C."xsd:string |
| http://purl.uniprot.org/citations/25071083 | http://purl.uniprot.org/core/author | "Lal M.A."xsd:string |
| http://purl.uniprot.org/citations/25071083 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25071083 | http://purl.uniprot.org/core/name | "J Am Soc Nephrol"xsd:string |
| http://purl.uniprot.org/citations/25071083 | http://purl.uniprot.org/core/pages | "647-662"xsd:string |
| http://purl.uniprot.org/citations/25071083 | http://purl.uniprot.org/core/title | "Rhophilin-1 is a key regulator of the podocyte cytoskeleton and is essential for glomerular filtration."xsd:string |
| http://purl.uniprot.org/citations/25071083 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/25071083 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25071083 |
| http://purl.uniprot.org/citations/25071083 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25071083 |
| http://purl.uniprot.org/uniprot/Q61085#attribution-2FDA9A97EE7A18AFB599D3DCD7DEF3F6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25071083 |
| http://purl.uniprot.org/uniprot/Q61085#attribution-D2D369ECB0E08F406488A071CAD4C0D0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25071083 |
| http://purl.uniprot.org/uniprot/Q8BWR8#attribution-6FC30D09FC9B05EC60AA144F97428C3B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25071083 |
| http://purl.uniprot.org/uniprot/Q8IUC4#attribution-2FDA9A97EE7A18AFB599D3DCD7DEF3F6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25071083 |
| http://purl.uniprot.org/uniprot/Q9QUI0#attribution-2FDA9A97EE7A18AFB599D3DCD7DEF3F6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25071083 |
| http://purl.uniprot.org/uniprot/Q9QUI0#attribution-6FC30D09FC9B05EC60AA144F97428C3B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25071083 |
| http://purl.uniprot.org/uniprot/Q62219#attribution-2FDA9A97EE7A18AFB599D3DCD7DEF3F6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25071083 |