| http://purl.uniprot.org/citations/25071155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25071155 | http://www.w3.org/2000/01/rdf-schema#comment | "The balance between transcription factor p73 and its functionally opposing N-terminally truncated ΔNp73 isoform is critical for cell survival, but the precise mechanism that regulates their levels is not clear. In our study, we identified WWP2, an E3 ligase, as a novel p73-associated protein that ubiquitinates and degrades p73. In contrast, WWP2 heterodimerizes with another E3 ligase, WWP1, which specifically ubiquitinates and degrades ΔNp73. Further, we identified phosphatase PPM1G as a functional switch that controls the balance between monomeric WWP2 and a WWP2/WWP1 heterodimeric state in the cell. During cellular stress, WWP2 is inactivated, leading to upregulation of p73, whereas WWP2-WWP1 complex is intact to degrade ΔNp73, thus playing an important role in shifting the balance between p73 and ΔNp73. Collectively, our results reveal a new functional E3 ligase complex controlled by PPM1G that differentially regulates cellular p73 and ΔNp73."xsd:string |
| http://purl.uniprot.org/citations/25071155 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00101-14"xsd:string |
| http://purl.uniprot.org/citations/25071155 | http://purl.uniprot.org/core/author | "Chaudhary N."xsd:string |
| http://purl.uniprot.org/citations/25071155 | http://purl.uniprot.org/core/author | "Maddika S."xsd:string |
| http://purl.uniprot.org/citations/25071155 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25071155 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/25071155 | http://purl.uniprot.org/core/pages | "3754-3764"xsd:string |
| http://purl.uniprot.org/citations/25071155 | http://purl.uniprot.org/core/title | "WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and DeltaNp73 levels."xsd:string |
| http://purl.uniprot.org/citations/25071155 | http://purl.uniprot.org/core/volume | "34"xsd:string |
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| http://purl.uniprot.org/uniprot/#_Q96IN7-mappedCitation-25071155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25071155 |