| http://purl.uniprot.org/citations/25071926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25071926 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundAs elegant structures designed for neural communication, synapses are the building bricks of our mental functions. Recently, many studies have pointed out that synaptic protein-associated mutations may lead to dysfunctions of social cognition. Dlgap2, which encodes one of the main components of scaffold proteins in postsynaptic density (PSD), has been addressed as a candidate gene in autism spectrum disorders. To elucidate the disturbance of synaptic balance arising from Dlgap2 loss-of-function in vivo, we thus generated Dlgap2 (-/-) mice to investigate their phenotypes of synaptic function and social behaviors.MethodsThe creation of Dlgap2 (-/-) mice was facilitated by the recombineering-based method, Cre-loxP system and serial backcross. Reversal learning in a water T-maze was used to determine repetitive behaviors. The three-chamber approach task, resident-intruder test and tube task were performed to characterize the social behaviors of mutant mice. Cortical synaptosomal fraction, Golgi-Cox staining, whole-cell patch electrophysiology and transmission electron microscopy were all applied to investigate the function and structure of synapses in the orbitofrontal cortex (OFC) of Dlgap2 (-/-) mice.ResultsDlgap2 (-/-) mice displayed exacerbated aggressive behaviors in the resident-intruder task, and elevated social dominance in the tube test. In addition, Dlgap2 (-/-) mice exhibited a clear reduction of receptors and scaffold proteins in cortical synapses. Dlgap2 (-/-) mice also demonstrated lower spine density, decreased peak amplitude of miniature excitatory postsynaptic current and ultra-structural deficits of PSD in the OFC.ConclusionsOur findings clearly demonstrate that Dlgap2 plays a vital role in social behaviors and proper synaptic functions of the OFC. Moreover, these results may provide valuable insights into the neuropathology of autism."xsd:string |
| http://purl.uniprot.org/citations/25071926 | http://purl.org/dc/terms/identifier | "doi:10.1186/2040-2392-5-32"xsd:string |
| http://purl.uniprot.org/citations/25071926 | http://purl.uniprot.org/core/author | "Chen C.H."xsd:string |
| http://purl.uniprot.org/citations/25071926 | http://purl.uniprot.org/core/author | "Lee L.J."xsd:string |
| http://purl.uniprot.org/citations/25071926 | http://purl.uniprot.org/core/author | "Ho S.Y."xsd:string |
| http://purl.uniprot.org/citations/25071926 | http://purl.uniprot.org/core/author | "Chen Y.T."xsd:string |
| http://purl.uniprot.org/citations/25071926 | http://purl.uniprot.org/core/author | "Liou H.H."xsd:string |
| http://purl.uniprot.org/citations/25071926 | http://purl.uniprot.org/core/author | "Gau S.S."xsd:string |
| http://purl.uniprot.org/citations/25071926 | http://purl.uniprot.org/core/author | "Fu W.M."xsd:string |
| http://purl.uniprot.org/citations/25071926 | http://purl.uniprot.org/core/author | "Lu D.H."xsd:string |
| http://purl.uniprot.org/citations/25071926 | http://purl.uniprot.org/core/author | "Liao H.M."xsd:string |
| http://purl.uniprot.org/citations/25071926 | http://purl.uniprot.org/core/author | "Jiang-Xie L.F."xsd:string |
| http://purl.uniprot.org/citations/25071926 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25071926 | http://purl.uniprot.org/core/name | "Mol Autism"xsd:string |
| http://purl.uniprot.org/citations/25071926 | http://purl.uniprot.org/core/pages | "32"xsd:string |
| http://purl.uniprot.org/citations/25071926 | http://purl.uniprot.org/core/title | "Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits."xsd:string |
| http://purl.uniprot.org/citations/25071926 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/25071926 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25071926 |
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| http://purl.uniprot.org/uniprot/Q8BJ42 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25071926 |