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| http://purl.uniprot.org/citations/25079692 | http://www.w3.org/2000/01/rdf-schema#comment | "Once adherens junctions (AJs) are formed between polarized epithelial cells they must be maintained because AJs are constantly remodeled in dynamic epithelia. AJ maintenance involves endocytosis and subsequent recycling of E-cadherin to a precise location along the basolateral membrane. In the Drosophila pupal eye epithelium, Rho1 GTPase regulates AJ remodeling through Drosophila E-cadherin (DE-cadherin) endocytosis by limiting Cdc42/Par6/aPKC complex activity. We demonstrate that Rho1 also influences AJ remodeling by regulating the formation of DE-cadherin-containing, Rab11-positive recycling endosomes in Drosophila postmitotic pupal eye epithelia. This effect of Rho1 is mediated through Rok-dependent, but not MLCK-dependent, stimulation of myosin II activity yet independent of its effects upon actin remodeling. Both Rho1 and pMLC localize on endosomal vesicles, suggesting that Rho1 might regulate the formation of recycling endosomes through localized myosin II activation. This work identifies spatially distinct functions for Rho1 in the regulation of DE-cadherin-containing vesicular trafficking during AJ remodeling in live epithelia."xsd:string |
| http://purl.uniprot.org/citations/25079692 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e14-04-0894"xsd:string |
| http://purl.uniprot.org/citations/25079692 | http://purl.uniprot.org/core/author | "Longmore G.D."xsd:string |
| http://purl.uniprot.org/citations/25079692 | http://purl.uniprot.org/core/author | "Skeath J.B."xsd:string |
| http://purl.uniprot.org/citations/25079692 | http://purl.uniprot.org/core/author | "Yashiro H."xsd:string |
| http://purl.uniprot.org/citations/25079692 | http://purl.uniprot.org/core/author | "Loza A.J."xsd:string |
| http://purl.uniprot.org/citations/25079692 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25079692 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/25079692 | http://purl.uniprot.org/core/pages | "2956-2969"xsd:string |
| http://purl.uniprot.org/citations/25079692 | http://purl.uniprot.org/core/title | "Rho1 regulates adherens junction remodeling by promoting recycling endosome formation through activation of myosin II."xsd:string |
| http://purl.uniprot.org/citations/25079692 | http://purl.uniprot.org/core/volume | "25"xsd:string |
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