| http://purl.uniprot.org/citations/25081541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25081541 | http://www.w3.org/2000/01/rdf-schema#comment | "Gene associated with retinoid and interferon-induced mortality 1 (GRIM-1) acts as a tumor growth suppressor via apoptosis induction. However, GRIM-1 expression in human non-small cell lung cancer (NSCLC) and its potential interaction with another apoptosis-associated protein-glucose-regulated protein 78 (GRP78)-are as yet unknown. Using 40 surgical specimens, we showed significantly lower expression of GRIM-1 in NSCLC at both protein and messenger RNA (mRNA) levels compared with that in normal tissues (P < .01 and P < .001, respectively). Interestingly, these tumors tended to express higher basal amounts of GRP78 protein and mRNA (P < .05 and P < .001, respectively). Similarly, in the NSCLC tissues, weaker staining for GRIM-1 (main intensity + to ++) but stronger staining for GRP78 (main intensity +++ to ++++) was observed. Correlation analysis showed that protein and mRNA expression or the percentage of cells immunoreactive for GRIM-1 was negatively correlated with that of GRP78 (r = -0.279, r = -0.326, or r = -0.571, respectively). Coimmunoprecipitation and transient transfection revealed that GRIM-1 interacted with GRP78 and suppressed GRP78 protein expression. In addition, there was no correlation between GRIM-1 expression and clinical characteristics, whereas GRP78 expression was significantly correlated with tumor-nodes-metastasis (TNM) stage (stage 3 + 4 versus stage 1 + 2). In conclusion, the expression of GRIM-1 and GRP78 was negatively correlated in human NSCLC tissues, and the down-regulation of GRP78 by GRIM-1 provides a possible mechanism for their interaction. This study suggests a novel potential molecular pathway inactivated during the development of NSCLC."xsd:string |
| http://purl.uniprot.org/citations/25081541 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humpath.2014.04.023"xsd:string |
| http://purl.uniprot.org/citations/25081541 | http://purl.uniprot.org/core/author | "Ma Y."xsd:string |
| http://purl.uniprot.org/citations/25081541 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/25081541 | http://purl.uniprot.org/core/author | "Wu H.M."xsd:string |
| http://purl.uniprot.org/citations/25081541 | http://purl.uniprot.org/core/author | "Fan X.Y."xsd:string |
| http://purl.uniprot.org/citations/25081541 | http://purl.uniprot.org/core/author | "Yan X.B."xsd:string |
| http://purl.uniprot.org/citations/25081541 | http://purl.uniprot.org/core/author | "Liu R.Y."xsd:string |
| http://purl.uniprot.org/citations/25081541 | http://purl.uniprot.org/core/author | "Jiang Z.F."xsd:string |
| http://purl.uniprot.org/citations/25081541 | http://purl.uniprot.org/core/author | "Xiao W.H."xsd:string |
| http://purl.uniprot.org/citations/25081541 | http://purl.uniprot.org/core/author | "Ke-Xu"xsd:string |
| http://purl.uniprot.org/citations/25081541 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25081541 | http://purl.uniprot.org/core/name | "Hum Pathol"xsd:string |
| http://purl.uniprot.org/citations/25081541 | http://purl.uniprot.org/core/pages | "1936-1943"xsd:string |
| http://purl.uniprot.org/citations/25081541 | http://purl.uniprot.org/core/title | "Reversed expression of GRIM-1 and GRP78 in human non-small cell lung cancer."xsd:string |
| http://purl.uniprot.org/citations/25081541 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/25081541 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25081541 |
| http://purl.uniprot.org/citations/25081541 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25081541 |
| http://purl.uniprot.org/uniprot/#_Q6PI26-mappedCitation-25081541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25081541 |
| http://purl.uniprot.org/uniprot/Q6PI26 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25081541 |