| http://purl.uniprot.org/citations/25085881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25085881 | http://www.w3.org/2000/01/rdf-schema#comment | "Cajal-Retzius (CR) cells are essential for cortical development and lamination. These pioneer neurons arise from distinct progenitor sources, including the cortical hem and the ventral pallium at pallium-subpallium boundary (PSB). CXCR4, the canonical receptor for the chemokine CXCL12, controls the superficial location of hem-derived CR cells. However, recent studies showed that CXCR7, a second CXCL12 receptor, is also expressed in CR cells at early developmental stages. We thus investigated the role of CXCR7 during CR cell development using multiple loss-of-function approaches. Cxcr7 gene inactivation led to aberrant localization of Reelin-positive cells within the pallium. In addition, Cxcr7(-/-) mice were characterized by significant accumulation of ectopic CR cells in the lateral part of the dorsal pallium compared with Cxcr4 knockout mice. Loss-of-function approaches, using either gene targeting or pharmacological receptor inhibition, reveal that CXCR7 and CXCR4 act both in CR positioning. Finally, conditional Cxcr7 deletion in cells derived from Dbx1-expressing progenitors indicates an essential role of CXCR7 in controlling the positioning of a subpopulation of PSB-derived CR cells. Our data demonstrate that CXCR7 has a role in the positioning of hem and PSB-derived CR cells, CXCL12 regulating CR cell subpial localization through the combined action of CXCR4 and CXCR7."xsd:string |
| http://purl.uniprot.org/citations/25085881 | http://purl.org/dc/terms/identifier | "doi:10.1093/cercor/bhu164"xsd:string |
| http://purl.uniprot.org/citations/25085881 | http://purl.uniprot.org/core/author | "Nagasawa T."xsd:string |
| http://purl.uniprot.org/citations/25085881 | http://purl.uniprot.org/core/author | "Pierani A."xsd:string |
| http://purl.uniprot.org/citations/25085881 | http://purl.uniprot.org/core/author | "Dutriaux A."xsd:string |
| http://purl.uniprot.org/citations/25085881 | http://purl.uniprot.org/core/author | "Bock H.H."xsd:string |
| http://purl.uniprot.org/citations/25085881 | http://purl.uniprot.org/core/author | "Rossel M."xsd:string |
| http://purl.uniprot.org/citations/25085881 | http://purl.uniprot.org/core/author | "Verdier J.M."xsd:string |
| http://purl.uniprot.org/citations/25085881 | http://purl.uniprot.org/core/author | "Trousse F."xsd:string |
| http://purl.uniprot.org/citations/25085881 | http://purl.uniprot.org/core/author | "Poluch S."xsd:string |
| http://purl.uniprot.org/citations/25085881 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25085881 | http://purl.uniprot.org/core/name | "Cereb Cortex"xsd:string |
| http://purl.uniprot.org/citations/25085881 | http://purl.uniprot.org/core/pages | "3446-3457"xsd:string |
| http://purl.uniprot.org/citations/25085881 | http://purl.uniprot.org/core/title | "CXCR7 Receptor Controls the Maintenance of Subpial Positioning of Cajal-Retzius Cells."xsd:string |
| http://purl.uniprot.org/citations/25085881 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/25085881 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25085881 |
| http://purl.uniprot.org/citations/25085881 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25085881 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0N8-mappedCitation-25085881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25085881 |
| http://purl.uniprot.org/uniprot/#_D3Z1L8-mappedCitation-25085881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25085881 |
| http://purl.uniprot.org/uniprot/#_D3Z5S3-mappedCitation-25085881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25085881 |
| http://purl.uniprot.org/uniprot/#_P52950-mappedCitation-25085881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25085881 |
| http://purl.uniprot.org/uniprot/#_P56485-mappedCitation-25085881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25085881 |
| http://purl.uniprot.org/uniprot/#_P70658-mappedCitation-25085881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25085881 |
| http://purl.uniprot.org/uniprot/#_A2AR81-mappedCitation-25085881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25085881 |